Analysis of Lymphocytic DNA Damage in Early Multiple Sclerosis by Automated Gamma-H2AX and 53BP1 Foci Detection: A Case Control Study

• Ludwig Rasche,

  Affiliations NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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• Lisa Heiserich,

  Affiliation Medipan GmbH, Berlin-Dahlewitz, Germany

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• Janina Ruth Behrens,

  Affiliations NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany

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• Klaus Lenz,

  Affiliation Department of Medical Biometrics and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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• Catherina Pfuhl,

  Affiliations NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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• Katharina Wakonig,

  Affiliations NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany

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• René Markus Gieß,

  Affiliations NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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• Erik Freitag,

  Affiliations NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany

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• Caroline Eberle,

  Affiliation Medipan GmbH, Berlin-Dahlewitz, Germany

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• Jens Wuerfel,

  Affiliations NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, MIAC AG, Basel, Switzerland, Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany, Institute of Neuroradiology, Universitätsmedizin Göttingen, Göttingen, Germany

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• Jan Dörr,

  Affiliations NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany

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• Peter Bauer,

  Affiliation Medipan GmbH, Berlin-Dahlewitz, Germany

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• Judith Bellmann-Strobl,

  Affiliations NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany

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• Friedemann Paul,

  Affiliations NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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• Dirk Roggenbuck ,

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Medipan GmbH, Berlin-Dahlewitz, Germany, Faculty of Science, Brandenburg University of Technology Cottbus - Senftenberg, Senftenberg, Germany

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•  [ ... ],
• Klemens Ruprecht

  * E-mail: klemens.ruprecht@charite.de

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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