Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye

Ji Hwan Min; Chul Hee Lee; Yong Woo Ji; Areum Yeo; Hyemi Noh; Insil Song; Eung Kweon Kim; Hyung Keun Lee

doi:10.1371/journal.pone.0147846

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Open Access

Peer-reviewed

Research Article

Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye

Ji Hwan Min ,

Contributed equally to this work with: Ji Hwan Min, Chul Hee Lee

Affiliation Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
⨯
Chul Hee Lee ,

Contributed equally to this work with: Ji Hwan Min, Chul Hee Lee

Affiliation Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
⨯
Yong Woo Ji,

Affiliations Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea, Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
⨯
Areum Yeo,

Affiliation Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
⨯
Hyemi Noh,

Affiliation Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
⨯
Insil Song,

Affiliation Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
⨯
Eung Kweon Kim,

Affiliations Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea, Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
⨯
Hyung Keun Lee

* E-mail: shadik@yuhs.ac

Affiliations Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea, Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea, Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Korea
⨯

Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye

Ji Hwan Min,
Chul Hee Lee,
Yong Woo Ji,
Areum Yeo,
Hyemi Noh,
Insil Song,
Eung Kweon Kim,
Hyung Keun Lee

Published: February 1, 2016
https://doi.org/10.1371/journal.pone.0147846

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Notch signaling
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