Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials

Andrew Fiore-Gartland; Bryce A. Manso; David P. Friedrich; Erin E. Gabriel; Greg Finak; Zoe Moodie; Tomer Hertz; Stephen C. De Rosa; Nicole Frahm; Peter B. Gilbert; M. Juliana McElrath

doi:10.1371/journal.pone.0147812

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Open Access

Peer-reviewed

Research Article

Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials

Andrew Fiore-Gartland ,

* E-mail: agartlan@fredhutch.org

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America
⨯
Bryce A. Manso,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America
⨯
David P. Friedrich,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America
⨯
Erin E. Gabriel,

Affiliation Biostatistics Research Branch, National Institute of Allergy and Infectious Disease, Rockville, Maryland, 20852, United States of America
⨯
Greg Finak,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America
⨯
Zoe Moodie,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America
⨯
Tomer Hertz,

Affiliation Shraga Segal Department of Microbiology, Immunology and Genetics, Ben Gurion Institute of the Negev, Beer-Sheva, 84105, Israel
⨯
Stephen C. De Rosa,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America
⨯
Nicole Frahm,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America
⨯
Peter B. Gilbert,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America
⨯
M. Juliana McElrath

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America
⨯

Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials

Andrew Fiore-Gartland,
Bryce A. Manso,
David P. Friedrich,
Erin E. Gabriel,
Greg Finak,
Zoe Moodie,
Tomer Hertz,
Stephen C. De Rosa,
Nicole Frahm,
Peter B. Gilbert

Published: February 10, 2016
https://doi.org/10.1371/journal.pone.0147812

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