Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study

Juho Pirhonen; Johanna Arola; Sanja Sädevirta; Panu Luukkonen; Sanna-Maria Karppinen; Taina Pihlajaniemi; Antti Isomäki; Mika Hukkanen; Hannele Yki-Järvinen; Elina Ikonen

doi:10.1371/journal.pone.0147804

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Open Access

Peer-reviewed

Research Article

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study

Juho Pirhonen ,

* E-mail: juho.pirhonen@helsinki.fi

Affiliations Departments of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland, Minerva Foundation Institute for Medical Research, Helsinki, Finland
⨯
Johanna Arola,

Affiliations Department of Pathology, Faculty of Medicine, University of Helsinki, Helsinki, Finland, Department of Pathology, HUSLAB, Helsinki, Finland
⨯
Sanja Sädevirta,

Affiliations Department of Medicine, Faculty of Medicine, University of Helsinki, Helsinki, Finland, Minerva Foundation Institute for Medical Research, Helsinki, Finland
⨯
Panu Luukkonen,

Affiliations Department of Medicine, Faculty of Medicine, University of Helsinki, Helsinki, Finland, Minerva Foundation Institute for Medical Research, Helsinki, Finland
⨯
Sanna-Maria Karppinen,

Affiliation Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, Biocenter Oulu, Oulu, Finland
⨯
Taina Pihlajaniemi,

Affiliation Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, Biocenter Oulu, Oulu, Finland
⨯
Antti Isomäki,

Affiliation Departments of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland
⨯
Mika Hukkanen,

Affiliation Departments of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland
⨯
Hannele Yki-Järvinen ,

Contributed equally to this work with: Hannele Yki-Järvinen, Elina Ikonen

Affiliations Department of Medicine, Faculty of Medicine, University of Helsinki, Helsinki, Finland, Minerva Foundation Institute for Medical Research, Helsinki, Finland
⨯
Elina Ikonen

Contributed equally to this work with: Hannele Yki-Järvinen, Elina Ikonen

Affiliations Departments of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland, Minerva Foundation Institute for Medical Research, Helsinki, Finland
⨯

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study

Juho Pirhonen,
Johanna Arola,
Sanja Sädevirta,
Panu Luukkonen,
Sanna-Maria Karppinen,
Taina Pihlajaniemi,
Antti Isomäki,
Mika Hukkanen,
Hannele Yki-Järvinen,
Elina Ikonen

Published: January 25, 2016
https://doi.org/10.1371/journal.pone.0147804

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Fibrosis
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Biopsy
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Fatty liver
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Liver fibrosis
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Image analysis
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