Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis

Wei Lu; Junhui Sun; Jeong Seon Yoon; Yan Zhang; Lixin Zheng; Elizabeth Murphy; Mark P. Mattson; Michael J. Lenardo

doi:10.1371/journal.pone.0147792

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Open Access

Peer-reviewed

Research Article

Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis

Wei Lu ,

Contributed equally to this work with: Wei Lu, Junhui Sun, Jeong Seon Yoon

Affiliation Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Junhui Sun ,

Contributed equally to this work with: Wei Lu, Junhui Sun, Jeong Seon Yoon

Affiliation Systems Biology Center,National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jeong Seon Yoon ,

Contributed equally to this work with: Wei Lu, Junhui Sun, Jeong Seon Yoon

Affiliation Cellular and Molecular Neuroscience Section, Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Yan Zhang,

Affiliation Molecular Mechanism of Apoptosis Section, Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Lixin Zheng,

Affiliation Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Elizabeth Murphy,

Affiliation Systems Biology Center,National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Mark P. Mattson,

Affiliation Cellular and Molecular Neuroscience Section, Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Michael J. Lenardo

* E-mail: lenardo@nih.gov

Affiliation Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis

Wei Lu,
Junhui Sun,
Jeong Seon Yoon,
Yan Zhang,
Lixin Zheng,
Elizabeth Murphy,
Mark P. Mattson,
Michael J. Lenardo

Published: January 25, 2016
https://doi.org/10.1371/journal.pone.0147792

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Heart
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Necrotic cell death
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Membrane proteins
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Cell viability testing
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