Phenotyping of UGT1A1 Activity Using Raltegravir Predicts Pharmacokinetics and Toxicity of Irinotecan in FOLFIRI

• Lawrence Soon-U Lee ,

  * E-mail: phcgbc@nus.edu.sg

  Affiliations Department of Medicine, National University Health System, Singapore, Singapore, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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• Kok-Yong Seng,

  Affiliation Department of Pharmacology, National University of Singapore, Singapore, Singapore

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• Ling-Zhi Wang,

  Affiliations Department of Pharmacology, National University of Singapore, Singapore, Singapore, Cancer Science Institute, National University of Singapore, Singapore, Singapore

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• Wei-Peng Yong,

  Affiliation Department of Haematology-Oncology, National University Health System, Singapore, Singapore

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• Kim-Hor Hee,

  Affiliation Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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• Thomas I. Soh,

  Affiliation Department of Haematology-Oncology, National University Health System, Singapore, Singapore

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• Andrea Wong,

  Affiliation Department of Haematology-Oncology, National University Health System, Singapore, Singapore

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• Pei F. Cheong,

  Affiliation Department of Haematology-Oncology, National University Health System, Singapore, Singapore

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• Richie Soong,

  Affiliation Department of Pharmacology, National University of Singapore, Singapore, Singapore

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• Nur S. Sapari,

  Affiliation Department of Pharmacology, National University of Singapore, Singapore, Singapore

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• Ross Soo,

  Affiliations Department of Medicine, National University Health System, Singapore, Singapore, Department of Pharmacology, National University of Singapore, Singapore, Singapore

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• Lu Fan,

  Affiliation Cancer Science Institute, National University of Singapore, Singapore, Singapore

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• Soo-Chin Lee,

  Affiliations Cancer Science Institute, National University of Singapore, Singapore, Singapore, Department of Haematology-Oncology, National University Health System, Singapore, Singapore

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• Boon C. Goh

  Affiliations Department of Pharmacology, National University of Singapore, Singapore, Singapore, Cancer Science Institute, National University of Singapore, Singapore, Singapore, Department of Haematology-Oncology, National University Health System, Singapore, Singapore

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