Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

Wen-Tian He; Xue-Ming Zheng; Yu-Hang Zhang; Yong-Guang Gao; Ai-Xin Song; Françoise Gisou van der Goot; Hong-Yu Hu

doi:10.1371/journal.pone.0147515

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Peer-reviewed

Research Article

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

Wen-Tian He ,

Contributed equally to this work with: Wen-Tian He, Xue-Ming Zheng

Affiliation State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
⨯
Xue-Ming Zheng ,

Contributed equally to this work with: Wen-Tian He, Xue-Ming Zheng

Affiliations State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, Department of Biochemistry and Molecular Biology, School of Medical Technology, Jiangsu University, Zhenjiang 212013, Jiangsu, China
⨯
Yu-Hang Zhang,

Affiliation State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
⨯
Yong-Guang Gao,

Affiliation State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
⨯
Ai-Xin Song,

Affiliation State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
⨯
Françoise Gisou van der Goot,

Affiliation Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
⨯
Hong-Yu Hu

* E-mail: hyhu@sibcb.ac.cn

Affiliation State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
⨯

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

Wen-Tian He,
Xue-Ming Zheng,
Yu-Hang Zhang,
Yong-Guang Gao,
Ai-Xin Song,
Françoise Gisou van der Goot,
Hong-Yu Hu

Published: January 25, 2016
https://doi.org/10.1371/journal.pone.0147515

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