Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells

Chao Zhang; Xuejing Jia; Kai Wang; Jiaolin Bao; Peng Li; Meiwan Chen; Jian-Bo Wan; Huanxing Su; Zhinan Mei; Chengwei He

doi:10.1371/journal.pone.0147405

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Open Access

Peer-reviewed

Research Article

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells

Chao Zhang,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
⨯
Xuejing Jia,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
⨯
Kai Wang,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
⨯
Jiaolin Bao,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
⨯
Peng Li,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
⨯
Meiwan Chen,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
⨯
Jian-Bo Wan,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
⨯
Huanxing Su,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
⨯
Zhinan Mei ,

* E-mail: chengweihe@umac.mo (CH); meizhinan@163.com (ZM)

Affiliation College of Pharmacy, South Central University for Nationalities, Wuhan 430074, China
⨯
Chengwei He

* E-mail: chengweihe@umac.mo (CH); meizhinan@163.com (ZM)

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
⨯

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells

Chao Zhang,
Xuejing Jia,
Kai Wang,
Jiaolin Bao,
Peng Li,
Meiwan Chen,
Jian-Bo Wan,
Huanxing Su,
Zhinan Mei,
Chengwei He

Published: January 25, 2016
https://doi.org/10.1371/journal.pone.0147405

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Autophagic cell death
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Apoptosis
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Cancer treatment
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Hepatocellular carcinoma
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c-Jun N-terminal kinase signaling cascade
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Breast cancer
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