Development of an Automated and Sensitive Microfluidic Device for Capturing and Characterizing Circulating Tumor Cells (CTCs) from Clinical Blood Samples

Priya Gogoi; Saedeh Sepehri; Yi Zhou; Michael A. Gorin; Carmela Paolillo; Ettore Capoluongo; Kyle Gleason; Austin Payne; Brian Boniface; Massimo Cristofanilli; Todd M. Morgan; Paolo Fortina; Kenneth J. Pienta; Kalyan Handique; Yixin Wang

doi:10.1371/journal.pone.0147400

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Open Access

Peer-reviewed

Research Article

Development of an Automated and Sensitive Microfluidic Device for Capturing and Characterizing Circulating Tumor Cells (CTCs) from Clinical Blood Samples

Priya Gogoi,

Affiliation Celsee Diagnostics, 46701 Commerce Center Drive, Plymouth, Michigan, United States of America
⨯
Saedeh Sepehri,

Affiliation Celsee Diagnostics, 46701 Commerce Center Drive, Plymouth, Michigan, United States of America
⨯
Yi Zhou,

Affiliation Celsee Diagnostics, 46701 Commerce Center Drive, Plymouth, Michigan, United States of America
⨯
Michael A. Gorin,

Affiliation The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Carmela Paolillo,

Affiliations Sidney Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Laboratory of Molecular Biology, Department of Laboratory Medicine, University Hospital “A. Gemelli”, Rome, Italy
⨯
Ettore Capoluongo,

Affiliation Laboratory of Molecular Biology, Department of Laboratory Medicine, University Hospital “A. Gemelli”, Rome, Italy
⨯
Kyle Gleason,

Affiliation Celsee Diagnostics, 46701 Commerce Center Drive, Plymouth, Michigan, United States of America
⨯
Austin Payne,

Affiliation Celsee Diagnostics, 46701 Commerce Center Drive, Plymouth, Michigan, United States of America
⨯
Brian Boniface,

Affiliation Celsee Diagnostics, 46701 Commerce Center Drive, Plymouth, Michigan, United States of America
⨯
Massimo Cristofanilli,

Affiliation Division of Hematology/Oncology, Robert Lurie Cancer Center, Northwestern University, Chicago, Illinois, United States of America
⨯
Todd M. Morgan,

Affiliation Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Paolo Fortina,

Affiliations Sidney Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Department of Molecular Medicine, University of Rome “Sapienza”, Rome, Italy
⨯
Kenneth J. Pienta,

Affiliation The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Kalyan Handique,

Affiliation Celsee Diagnostics, 46701 Commerce Center Drive, Plymouth, Michigan, United States of America
⨯
Yixin Wang

* E-mail: ywang@celsee.com

Affiliation Celsee Diagnostics, 46701 Commerce Center Drive, Plymouth, Michigan, United States of America
⨯

Development of an Automated and Sensitive Microfluidic Device for Capturing and Characterizing Circulating Tumor Cells (CTCs) from Clinical Blood Samples

Priya Gogoi,
Saedeh Sepehri,
Yi Zhou,
Michael A. Gorin,
Carmela Paolillo,
Ettore Capoluongo,
Kyle Gleason,
Austin Payne,
Brian Boniface,
Massimo Cristofanilli

Published: January 25, 2016
https://doi.org/10.1371/journal.pone.0147400

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