Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE₂

• Emily Yun-Chia Chang,

  Affiliation Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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• Yi-Cheng Chang,

  Affiliations Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan, Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, Center for Obesity, Life style and Metabolic Surgery, National Taiwan University Hospital, Taipei, Taiwan

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• Chia-Tung Shun,

  Affiliation Department of Forensic Medicine and Pathology, National Taiwan University Hospital, Taipei, Taiwan

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• Yu-Wen Tien,

  Affiliation Department of Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Shu-Huei Tsai,

  Affiliation Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada

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• Siow-Wey Hee,

  Affiliation Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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• Ing-Jung Chen,

  Affiliation Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Lee-Ming Chuang

  * E-mail: leeming@ntu.edu.tw

  Affiliations Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

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