Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling

Jiaojiao Pang; Nathan D. Fuller; Nan Hu; Linzi A. Barton; Jeremy M. Henion; Rui Guo; Yuguo Chen; Jun Ren

doi:10.1371/journal.pone.0147322

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Peer-reviewed

Research Article

Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling

Jiaojiao Pang,

Affiliations Department of Emergency, Qilu Hospital of Shandong University, Jinan, Shandong, PR China, Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY, United States of America
⨯
Nathan D. Fuller,

Affiliation Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY, United States of America
⨯
Nan Hu,

Affiliation Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY, United States of America
⨯
Linzi A. Barton,

Affiliation Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY, United States of America
⨯
Jeremy M. Henion,

Affiliation Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY, United States of America
⨯
Rui Guo,

Affiliation Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY, United States of America
⨯
Yuguo Chen ,

* E-mail: jren@uwyo.edu (JR); chen919085@126.com (YC)

Affiliation Department of Emergency, Qilu Hospital of Shandong University, Jinan, Shandong, PR China
⨯
Jun Ren

* E-mail: jren@uwyo.edu (JR); chen919085@126.com (YC)

Affiliations Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY, United States of America, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, PR China
⨯

Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling

Jiaojiao Pang,
Nathan D. Fuller,
Nan Hu,
Linzi A. Barton,
Jeremy M. Henion,
Rui Guo,
Yuguo Chen,
Jun Ren

Published: January 25, 2016
https://doi.org/10.1371/journal.pone.0147322

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Autophagic cell death
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Cardiomyocytes
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Endoplasmic reticulum
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Oxidative stress
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Cardiovascular diseases
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