The Role of Hippocampal NMDA Receptors in Long-Term Emotional Responses following Muscarinic Receptor Activation

Alexandre A. Hoeller; Ana Paula R. Costa; Maíra A. Bicca; Filipe C. Matheus; Gilliard Lach; Francesca Spiga; Stafford L. Lightman; Roger Walz; Graham L. Collingridge; Zuner A. Bortolotto; Thereza C. M. de Lima

doi:10.1371/journal.pone.0147293

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Open Access

Peer-reviewed

Research Article

The Role of Hippocampal NMDA Receptors in Long-Term Emotional Responses following Muscarinic Receptor Activation

Alexandre A. Hoeller ,

* E-mail: alexandrehoeller@gmail.com (AAH); thereza.lima@ufsc.br (TCML)

Affiliations Postgraduate Program in Medical Sciences, Center of Health Sciences, University Hospital, Federal University of Santa Catarina, Florianópolis, SC, 88040–970, Brazil, Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040–970, Brazil, Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Dorothy Hodgkin Building, Bristol, BS1 3NY, United Kingdom
⨯
Ana Paula R. Costa,

Affiliation Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040–970, Brazil
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Maíra A. Bicca,

Affiliation Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040–970, Brazil
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Filipe C. Matheus,

Affiliation Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040–970, Brazil
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Gilliard Lach,

Affiliations Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040–970, Brazil, Institute of Pharmacology, Innsbruck Medical University, Innsbruck, 6020, Austria
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Francesca Spiga,

Affiliation Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Bristol, BS1 3NY, United Kingdom
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Stafford L. Lightman,

Affiliation Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Bristol, BS1 3NY, United Kingdom
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Roger Walz,

Affiliations Postgraduate Program in Medical Sciences, Center of Health Sciences, University Hospital, Federal University of Santa Catarina, Florianópolis, SC, 88040–970, Brazil, Department of Clinical Medicine, Center of Health Sciences, University Hospital, Federal University of Santa Catarina, Florianópolis, SC, 88040–970, Brazil
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Graham L. Collingridge,

Affiliation Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Dorothy Hodgkin Building, Bristol, BS1 3NY, United Kingdom
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Zuner A. Bortolotto,

Affiliation Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Dorothy Hodgkin Building, Bristol, BS1 3NY, United Kingdom
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Thereza C. M. de Lima

* E-mail: alexandrehoeller@gmail.com (AAH); thereza.lima@ufsc.br (TCML)

Affiliation Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040–970, Brazil
⨯

The Role of Hippocampal NMDA Receptors in Long-Term Emotional Responses following Muscarinic Receptor Activation

Alexandre A. Hoeller,
Ana Paula R. Costa,
Maíra A. Bicca,
Filipe C. Matheus,
Gilliard Lach,
Francesca Spiga,
Stafford L. Lightman,
Roger Walz,
Graham L. Collingridge,
Zuner A. Bortolotto

Published: January 21, 2016
https://doi.org/10.1371/journal.pone.0147293

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Receptor antagonist therapy
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Muscarinic acetylcholine receptors
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