Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

Ingrid C. Rulifson; Ping Cao; Li Miao; David Kopecky; Linda Huang; Ryan D. White; Kim Samayoa; Jonitha Gardner; Xiaosu Wu; Kui Chen; Trace Tsuruda; Oliver Homann; Helene Baribault; Harvey Yamane; Tim Carlson; Jed Wiltzius; Yang Li

doi:10.1371/journal.pone.0147254

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Open Access

Peer-reviewed

Research Article

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

Ingrid C. Rulifson ,

* E-mail: ingridr@amgen.com

Affiliation Amgen, Cardiometabolic Disorders, South San Francisco, California, United States of America
⨯
Ping Cao,

Affiliation Amgen, Molecular Structure and Characterization, South San Francisco, California, United States of America
⨯
Li Miao,

Affiliation Amgen, Cardiometabolic Disorders, South San Francisco, California, United States of America
⨯
David Kopecky,

Affiliation Amgen, Medicinal Chemistry, Thousand Oaks, California, United States of America
⨯
Linda Huang,

Affiliation Amgen, Molecular Structure and Characterization, South San Francisco, California, United States of America
⨯
Ryan D. White,

Affiliation Amgen, Medicinal Chemistry, Cambridge, Massachusetts, United States of America
⨯
Kim Samayoa,

Affiliation Amgen, Pathology, South San Francisco, California, United States of America
⨯
Jonitha Gardner,

Affiliation Amgen, Cardiometabolic Disorders, South San Francisco, California, United States of America
⨯
Xiaosu Wu,

Affiliation Amgen, Cardiometabolic Disorders, South San Francisco, California, United States of America
⨯
Kui Chen,

Affiliation Amgen, Discovery Technologies, Thousand Oaks, California, United States of America
⨯
Trace Tsuruda,

Affiliation Amgen, Biologics, Thousand Oaks, California, United States of America
⨯
Oliver Homann,

Affiliation Amgen, Genome Analysis Unit, South San Francisco, California, United States of America
⨯
Helene Baribault,

Affiliation Amgen, Cardiometabolic Disorders, South San Francisco, California, United States of America
⨯
Harvey Yamane,

Affiliation Amgen, Biologics, Thousand Oaks, California, United States of America
⨯
Tim Carlson,

Affiliation Amgen, Pharmacokinetics and Drug Metabolism, South San Francisco, California, United States of America
⨯
Jed Wiltzius,

Affiliation Amgen, Genome Analysis Unit, South San Francisco, California, United States of America
⨯
[ ... ],
Yang Li

Affiliation Amgen, Cardiometabolic Disorders, South San Francisco, California, United States of America
⨯
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Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

Ingrid C. Rulifson,
Ping Cao,
Li Miao,
David Kopecky,
Linda Huang,
Ryan D. White,
Kim Samayoa,
Jonitha Gardner,
Xiaosu Wu,
Kui Chen

Published: February 3, 2016
https://doi.org/10.1371/journal.pone.0147254

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