Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

Katherine Sullivan; Kimberly Cramer-Morales; Daniel L. McElroy; David A. Ostrov; Kimberly Haas; Wayne Childers; Robert Hromas; Tomasz Skorski

doi:10.1371/journal.pone.0147230

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Peer-reviewed

Research Article

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

Katherine Sullivan ,

Contributed equally to this work with: Katherine Sullivan, Kimberly Cramer-Morales

Affiliation Department of Microbiology and Immunology and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, United States of America
⨯
Kimberly Cramer-Morales ,

Contributed equally to this work with: Katherine Sullivan, Kimberly Cramer-Morales

Affiliation Department of Microbiology and Immunology and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, United States of America
⨯
Daniel L. McElroy,

Affiliation Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida & Shands, Gainesville, Florida 32610, United States of America
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David A. Ostrov,

Affiliation Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida & Shands, Gainesville, Florida 32610, United States of America
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Kimberly Haas,

Affiliation Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, United States of America
⨯
Wayne Childers,

Affiliation Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, United States of America
⨯
Robert Hromas,

Affiliation Department of Medicine, College of Medicine, University of Florida & Shands, Gainesville, Florida 32610, United States of America
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Tomasz Skorski

* E-mail: tskorski@temple.edu

Affiliation Department of Microbiology and Immunology and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, United States of America
⨯

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

Katherine Sullivan,
Kimberly Cramer-Morales,
Daniel L. McElroy,
David A. Ostrov,
Kimberly Haas,
Wayne Childers,
Robert Hromas,
Tomasz Skorski

Published: January 19, 2016
https://doi.org/10.1371/journal.pone.0147230

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