Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

Angela Corona; Rita Meleddu; Francesca Esposito; Simona Distinto; Giulia Bianco; Takashi Masaoka; Elias Maccioni; Luis Menéndez-Arias; Stefano Alcaro; Stuart F. J. Le Grice; Enzo Tramontano

doi:10.1371/journal.pone.0147225

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Open Access

Peer-reviewed

Research Article

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

Angela Corona,

Affiliation Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy
⨯
Rita Meleddu,

Affiliation Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy
⨯
Francesca Esposito,

Affiliation Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy
⨯
Simona Distinto,

Affiliation Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy
⨯
Giulia Bianco,

Affiliation Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy
⨯
Takashi Masaoka,

Affiliation National Cancer Institute, Frederick, Maryland, United States of America
⨯
Elias Maccioni,

Affiliation Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy
⨯
Luis Menéndez-Arias,

Affiliation Centro de Biología Molecular “Severo Ochoa” (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Madrid, Spain
⨯
Stefano Alcaro,

Affiliation Dipartimento di Scienze della Salute, Università Magna Graecia di Catanzaro, Campus “S. Venuta”, Viale Europa, 88100, Catanzaro, Italy
⨯
Stuart F. J. Le Grice,

Affiliation National Cancer Institute, Frederick, Maryland, United States of America
⨯
Enzo Tramontano

* E-mail: tramon@unica.it

Affiliations Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy, Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy
⨯

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

Angela Corona,
Rita Meleddu,
Francesca Esposito,
Simona Distinto,
Giulia Bianco,
Takashi Masaoka,
Elias Maccioni,
Luis Menéndez-Arias,
Stefano Alcaro,
Stuart F. J. Le Grice

Published: January 22, 2016
https://doi.org/10.1371/journal.pone.0147225

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