Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling

Lifeng Jia; Qi Song; Chenyang Zhou; Xiaoming Li; Lihong Pi; Xiuru Ma; Hui Li; Xiuying Lu; Yupeng Shen

doi:10.1371/journal.pone.0147157

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Peer-reviewed

Research Article

Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling

Lifeng Jia,

Affiliations Postgraduate School, The Third Medical Military University, Chongqing, 400038, China, Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, 050081, Hebei Province, China
⨯
Qi Song,

Affiliations Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, 050081, Hebei Province, China, Postgraduate School, Medical College of PLA, Beijing, 100700, China
⨯
Chenyang Zhou,

Affiliations Postgraduate School, The Third Medical Military University, Chongqing, 400038, China, Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, 050081, Hebei Province, China
⨯
Xiaoming Li ,

* E-mail: xmlmo@126.com

Affiliation Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, 050081, Hebei Province, China
⨯
Lihong Pi,

Affiliation Department of Otolaryngology, Hebei General Hospital, Shijiazhuang, 050051, Hebei Province, China
⨯
Xiuru Ma,

Affiliation Department of Basic Sciences, Hebei College of Traditional Chinese Medicine, Shijiazhuang, 050061, Hebei Province, China
⨯
Hui Li,

Affiliation Department of Pathology, Bethune International Peace Hospital, Shijiazhuang, 050081, Hebei, Province, China
⨯
Xiuying Lu,

Affiliation Postgraduate School, The Third Medical Military University, Chongqing, 400038, China
⨯
Yupeng Shen

Affiliation Postgraduate School, The Third Medical Military University, Chongqing, 400038, China
⨯

Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling

Lifeng Jia,
Qi Song,
Chenyang Zhou,
Xiaoming Li,
Lihong Pi,
Xiuru Ma,
Hui Li,
Xiuying Lu,
Yupeng Shen

Published: January 19, 2016
https://doi.org/10.1371/journal.pone.0147157

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Cancers and neoplasms
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STAT signaling
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Head and neck squamous cell carcinoma
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