A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion

Magdalena L. Circu; Samantha S. Dykes; Jennifer Carroll; Kinsey Kelly; Floyd Galiano; Adam Greer; James Cardelli; Hazem El-Osta

doi:10.1371/journal.pone.0146931

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Peer-reviewed

Research Article

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion

Magdalena L. Circu,

Affiliation Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Samantha S. Dykes,

Affiliations Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Jennifer Carroll,

Affiliation Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Kinsey Kelly,

Affiliation Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Floyd Galiano,

Affiliation Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Adam Greer,

Affiliation Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
James Cardelli,

Affiliations Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Hazem El-Osta

* E-mail: helost@lsuhsc.edu

Affiliation Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion

Magdalena L. Circu,
Samantha S. Dykes,
Jennifer Carroll,
Kinsey Kelly,
Floyd Galiano,
Adam Greer,
James Cardelli,
Hazem El-Osta

Published: January 19, 2016
https://doi.org/10.1371/journal.pone.0146931

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