L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice

Hao Hong; Christine E. Brown; Julie R. Ostberg; Saul J. Priceman; Wen-Chung Chang; Lihong Weng; Paul Lin; Mark T. Wakabayashi; Michael C. Jensen; Stephen J. Forman

doi:10.1371/journal.pone.0146885

Loading metrics

Open Access

Peer-reviewed

Research Article

L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice

Hao Hong,

Affiliation Department of Cancer Immunotherapeutics & Tumor Immunology and Hematology & Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
⨯
Christine E. Brown,

Affiliation Department of Cancer Immunotherapeutics & Tumor Immunology and Hematology & Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
⨯
Julie R. Ostberg,

Affiliation Department of Cancer Immunotherapeutics & Tumor Immunology and Hematology & Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
⨯
Saul J. Priceman,

Affiliation Department of Cancer Immunotherapeutics & Tumor Immunology and Hematology & Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
⨯
Wen-Chung Chang,

Affiliation Department of Cancer Immunotherapeutics & Tumor Immunology and Hematology & Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
⨯
Lihong Weng,

Affiliation Department of Cancer Immunotherapeutics & Tumor Immunology and Hematology & Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
⨯
Paul Lin,

Affiliation Department of Gynecologic Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
⨯
Mark T. Wakabayashi,

Affiliation Department of Gynecologic Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
⨯
Michael C. Jensen ,

* E-mail: michael.jensen@seattlechildrens.org (MCJ); sforman@coh.org (SJF)

Affiliation Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America
⨯
Stephen J. Forman

* E-mail: michael.jensen@seattlechildrens.org (MCJ); sforman@coh.org (SJF)

Affiliation Department of Cancer Immunotherapeutics & Tumor Immunology and Hematology & Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
⨯

L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice

Hao Hong,
Christine E. Brown,
Julie R. Ostberg,
Saul J. Priceman,
Wen-Chung Chang,
Lihong Weng,
Paul Lin,
Mark T. Wakabayashi,
Michael C. Jensen,
Stephen J. Forman

Published: January 13, 2016
https://doi.org/10.1371/journal.pone.0146885

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Ovarian cancer
Is the Subject Area "Ovarian cancer" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Ascites
Is the Subject Area "Ascites" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Cancer immunotherapy
Is the Subject Area "Cancer immunotherapy" applicable to this article?

Thanks for your feedback.
Gynecologic cancers
Is the Subject Area "Gynecologic cancers" applicable to this article?

Thanks for your feedback.
Renal cancer
Is the Subject Area "Renal cancer" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.