Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model

Pornswan Ngamprasertwong; Min Dong; Jing Niu; Raja Venkatasubramanian; Alexander A. Vinks; Senthilkumar Sadhasivam

doi:10.1371/journal.pone.0146563

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Research Article

Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model

Pornswan Ngamprasertwong ,

Contributed equally to this work with: Pornswan Ngamprasertwong, Min Dong

* E-mail: pornswan.ngamprasertwong@cchmc.org

Affiliation Department of Anesthesiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America
⨯
Min Dong ,

Contributed equally to this work with: Pornswan Ngamprasertwong, Min Dong

Affiliation Division of Clinical Pharmacology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America
⨯
Jing Niu,

Affiliations Department of Anesthesiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America, Division of Clinical Pharmacology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America, Department of Anesthesia, Shanghai Children’s Medical Center, Shanghai, China
⨯
Raja Venkatasubramanian,

Affiliations Department of Anesthesiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America, Division of Clinical Pharmacology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America
⨯
Alexander A. Vinks,

Affiliation Division of Clinical Pharmacology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America
⨯
Senthilkumar Sadhasivam

Affiliation Department of Anesthesiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America
⨯

Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model

Pornswan Ngamprasertwong,
Min Dong,
Jing Niu,
Raja Venkatasubramanian,
Alexander A. Vinks,
Senthilkumar Sadhasivam

Published: January 11, 2016
https://doi.org/10.1371/journal.pone.0146563

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