The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation

Tomohiro Okamoto; Yoko Ozawa; Mamoru Kamoshita; Hideto Osada; Eriko Toda; Toshihide Kurihara; Norihiro Nagai; Kazuo Umezawa; Kazuo Tsubota

doi:10.1371/journal.pone.0146517

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Open Access

Peer-reviewed

Research Article

The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation

Tomohiro Okamoto,

Affiliations Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan
⨯
Yoko Ozawa ,

* E-mail: ozawa@a5.keio.jp

Affiliations Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan
⨯
Mamoru Kamoshita,

Affiliations Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan
⨯
Hideto Osada,

Affiliation Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan
⨯
Eriko Toda,

Affiliation Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan
⨯
Toshihide Kurihara,

Affiliations Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan
⨯
Norihiro Nagai,

Affiliations Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan
⨯
Kazuo Umezawa,

Affiliation Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakute, Aichi, 480–1195, Japan
⨯
Kazuo Tsubota

Affiliation Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160–8582, Japan
⨯

The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation

Tomohiro Okamoto,
Yoko Ozawa,
Mamoru Kamoshita,
Hideto Osada,
Eriko Toda,
Toshihide Kurihara,
Norihiro Nagai,
Kazuo Umezawa,
Kazuo Tsubota

Published: January 15, 2016
https://doi.org/10.1371/journal.pone.0146517

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