Folate Deficiency Triggered Apoptosis of Synoviocytes: Role of Overproduction of Reactive Oxygen Species Generated via NADPH Oxidase/Mitochondrial Complex II and Calcium Perturbation

• Hung-Chih Hsu ,

  Contributed equally to this work with: Hung-Chih Hsu, Wen-Ming Chang

  Affiliations Department of Physical Medicine and Rehabilitation, Chia-Yi Chang Gung Memorial Hospital, Chia-Yi, Taiwan, Department of Nursing, Chang-Gung University of Science and Technology, Chia-Yi, Taiwan, Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Center of Advanced Integrative Sports Medicine, Chia-Yi Chang Gung Memorial Hospital, Chia-Yi, Taiwan

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• Wen-Ming Chang ,

  Contributed equally to this work with: Hung-Chih Hsu, Wen-Ming Chang

  Affiliations Department of Physical Medicine and Rehabilitation, Chia-Yi Chang Gung Memorial Hospital, Chia-Yi, Taiwan, Department of Nursing, Chang-Gung University of Science and Technology, Chia-Yi, Taiwan

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• Jin-Yi Wu,

  Affiliation Department of Microbiology, Immunology and Biopharmaceuticals, Collage of Life Sciences, National Chiayi University, Chiayi City 60004, Taiwan

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• Chin-Chin Huang,

  Affiliation Department of Microbiology, Immunology and Biopharmaceuticals, Collage of Life Sciences, National Chiayi University, Chiayi City 60004, Taiwan

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• Fung-Jou Lu,

  Affiliation Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

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• Yi-Wen Chuang,

  Affiliations Department of Physical Medicine and Rehabilitation, Chia-Yi Chang Gung Memorial Hospital, Chia-Yi, Taiwan, Department of Nursing, Chang-Gung University of Science and Technology, Chia-Yi, Taiwan

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• Pey-Jium Chang,

  Affiliation Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan

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• Kai-Hua Chen,

  Affiliations Department of Physical Medicine and Rehabilitation, Chia-Yi Chang Gung Memorial Hospital, Chia-Yi, Taiwan, Department of Nursing, Chang-Gung University of Science and Technology, Chia-Yi, Taiwan

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• Chang-Zern Hong,

  Affiliation Department of Physical therapy, Hung Kuang University, Taichung, Taiwan

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• Rang-Hui Yeh,

  Affiliation Department of Physical Medicine and Rehabilitation, Chia-Yi Chang Gung Memorial Hospital, Chia-Yi, Taiwan

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• Tsan-Zon Liu ,

  * E-mail: tzliu@tmuh.org.tw (TZL); chench@mail.ncyu.edu.tw (CHC)

  Affiliation Translational Research Laboratory, Cancer Center, Taipei Medical University and Hospital, Taipei, Taiwan

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• Ching-Hsein Chen

  * E-mail: tzliu@tmuh.org.tw (TZL); chench@mail.ncyu.edu.tw (CHC)

  Affiliation Department of Microbiology, Immunology and Biopharmaceuticals, Collage of Life Sciences, National Chiayi University, Chiayi City 60004, Taiwan

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