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Open Access
Peer-reviewed
Research Article
A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis
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Sanford D. Markowitz ,
Contributed equally to this work with: Sanford D. Markowitz, Nora L. Nock
* E-mail: sanford.markowitz@case.edu (SDM); rennert@techunix.technion.ac.il (GR); sgruber@med.usc.edu (SBG)
Affiliations Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
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Nora L. Nock ,
Contributed equally to this work with: Sanford D. Markowitz, Nora L. Nock
Affiliations Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
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Stephanie L. Schmit,
Affiliations Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
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Zsofia K. Stadler,
Affiliation Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
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Vijai Joseph,
Affiliation Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
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Lu Zhang,
Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America
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Joseph E. Willis,
Affiliations Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
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Peter Scacheri,
Affiliations Department of Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
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Martina Veigl,
Affiliation Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
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Mark D. Adams,
Current address: Craig Venter Institute, La Jolla, California, United States of America
Affiliation Department of Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America
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Leon Raskin,
Affiliation Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, United States of America
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John F. Sullivan,
Affiliation Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
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Kelly Stratton,
Affiliation Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
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Jinru Shia,
Affiliation Department of Pathology, Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, 10065, United States of America
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Nathan Ellis,
Affiliation The University of Arizona Cancer Center, Tucson, Arizona, United States of America
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Hedy S. Rennert,
Affiliations Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel, Clalit Health Services, National Cancer Control Center, Haifa, Israel, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
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Christopher Manschreck,
Affiliation Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
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Li Li,
Affiliations Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
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Kenneth Offit,
Affiliation Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
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Robert C. Elston,
Affiliations Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
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Gadi Rennert ,
* E-mail: sanford.markowitz@case.edu (SDM); rennert@techunix.technion.ac.il (GR); sgruber@med.usc.edu (SBG)
Affiliations Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel, Clalit Health Services, National Cancer Control Center, Haifa, Israel, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
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Stephen B. Gruber
* E-mail: sanford.markowitz@case.edu (SDM); rennert@techunix.technion.ac.il (GR); sgruber@med.usc.edu (SBG)
Affiliations Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
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A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis
- Sanford D. Markowitz,
- Nora L. Nock,
- Stephanie L. Schmit,
- Zsofia K. Stadler,
- Vijai Joseph,
- Lu Zhang,
- Joseph E. Willis,
- Peter Scacheri,
- Martina Veigl,
- Mark D. Adams
- Published: January 11, 2016
- https://doi.org/10.1371/journal.pone.0146435