Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses

Uri Sela; Chae Gyu Park; Andrew Park; Peter Olds; Shu Wang; Ralph M. Steinman; Vincent A. Fischetti

doi:10.1371/journal.pone.0146412

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Peer-reviewed

Research Article

Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses

Uri Sela ,

* E-mail: usela@rockefeller.edu

Affiliations Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Disease, The Rockefeller University, New York, NY, 10065, United States of America, Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY, 10065, United States of America
⨯
Chae Gyu Park,

Affiliations Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Disease, The Rockefeller University, New York, NY, 10065, United States of America, Laboratory of Immunology, Brain Korea 21 PLUS Project for Medical Science, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea
⨯
Andrew Park,

Affiliation Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Disease, The Rockefeller University, New York, NY, 10065, United States of America
⨯
Peter Olds,

Affiliation Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Disease, The Rockefeller University, New York, NY, 10065, United States of America
⨯
Shu Wang,

Affiliation Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY, 10065, United States of America
⨯
Ralph M. Steinman †,

† Deceased.

Affiliation Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Disease, The Rockefeller University, New York, NY, 10065, United States of America
⨯
Vincent A. Fischetti

Affiliation Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY, 10065, United States of America
⨯

Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses

Uri Sela,
Chae Gyu Park,
Andrew Park,
Peter Olds,
Shu Wang,
Ralph M. Steinman,
Vincent A. Fischetti

Published: January 8, 2016
https://doi.org/10.1371/journal.pone.0146412

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