Mutations to Less-Preferred Synonymous Codons in a Highly Expressed Gene of Escherichia coli: Fitness and Epistatic Interactions

Open Access

Peer-reviewed

Research Article

David J. Hauber,

Affiliation Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Dennis W. Grogan,

Affiliation Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Ronald W. DeBry

* E-mail: ron.debry@uc.edu

Affiliation Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯

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Silent mutation
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Natural selection
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Gene expression
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Mutation
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Cloning
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Mutant strains
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Fitness epistasis
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Plasmid construction
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