The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for TH1 Induction

Open Access

Peer-reviewed

Research Article

The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for T_H1 Induction

Natasha Dubois Cauwelaert,

Affiliation Infectious Disease Research Institute, Seattle, Washington, United States of America
⨯
Anthony L. Desbien,

Current address: Aduro Biotech, Berkeley, California, United States of America.

Affiliation Infectious Disease Research Institute, Seattle, Washington, United States of America
⨯
Thomas E. Hudson,

Affiliation Infectious Disease Research Institute, Seattle, Washington, United States of America
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Samuel O. Pine,

Current address: Allergan, Irvine, California, United States of America.

Affiliation Infectious Disease Research Institute, Seattle, Washington, United States of America
⨯
Steven G. Reed,

Affiliations Infectious Disease Research Institute, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America
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Rhea N. Coler,

Affiliations Infectious Disease Research Institute, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America
⨯
Mark T. Orr

* E-mail: mark.orr@idri.org

Affiliations Infectious Disease Research Institute, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America
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Immunologic adjuvants
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T cells
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Cell staining
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T helper cells
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Immune response
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Cytotoxic T cells
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Lymphocytes
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Enzyme-linked immunoassays
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