The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin

Lilach Moyal; Nataly Feldbaum; Neta Goldfeiz; Ada Rephaeli; Abraham Nudelman; Michal Weitman; Nataly Tarasenko; Batia Gorovitz; Leah Maron; Shiran Yehezkel; Iris Amitay-Laish; Ido Lubin; Emmilia Hodak

doi:10.1371/journal.pone.0146115

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Peer-reviewed

Research Article

The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin

Lilach Moyal ,

Contributed equally to this work with: Lilach Moyal, Nataly Feldbaum

* E-mail: lilachm@post.tau.ac.il

Affiliations Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, Department of Dermatology, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Nataly Feldbaum ,

Contributed equally to this work with: Lilach Moyal, Nataly Feldbaum

Affiliation Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Neta Goldfeiz,

Affiliation Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Ada Rephaeli,

Affiliation Laboratory for Pharmacology and Experimental Oncology, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Abraham Nudelman,

Affiliation Division of Medicinal Chemistry, Department of Chemistry, Bar Ilan University, Ramat Gan, Israel
⨯
Michal Weitman,

Affiliation Division of Medicinal Chemistry, Department of Chemistry, Bar Ilan University, Ramat Gan, Israel
⨯
Nataly Tarasenko,

Affiliation Laboratory for Pharmacology and Experimental Oncology, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Batia Gorovitz,

Affiliation Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Leah Maron,

Affiliation Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Shiran Yehezkel,

Affiliation Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Iris Amitay-Laish,

Affiliation Department of Dermatology, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Ido Lubin,

Affiliation Core Facility, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Emmilia Hodak

Affiliations Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, Department of Dermatology, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯

The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin

Lilach Moyal,
Nataly Feldbaum,
Neta Goldfeiz,
Ada Rephaeli,
Abraham Nudelman,
Michal Weitman,
Nataly Tarasenko,
Batia Gorovitz,
Leah Maron,
Shiran Yehezkel

Published: January 11, 2016
https://doi.org/10.1371/journal.pone.0146115

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