The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD

Kirsty E. Russell; Kian Fan Chung; Colin J. Clarke; Andrew L. Durham; Patrick Mallia; Joseph Footitt; Sebastian L. Johnston; Peter J. Barnes; Simon R. Hall; Karen D. Simpson; Malcolm R. Starkey; Philip M. Hansbro; Ian M. Adcock; Coen H. Wiegman

doi:10.1371/journal.pone.0146102

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Open Access

Peer-reviewed

Research Article

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD

Kirsty E. Russell,

Affiliation Airway Disease Section, National Heart & Lung Institute, NIHR Respiratory Biomedical Research Unit at the Royal Brompton NHS Foundation Trust and Imperial College London, London, United Kingdom
⨯
Kian Fan Chung,

Affiliation Airway Disease Section, National Heart & Lung Institute, NIHR Respiratory Biomedical Research Unit at the Royal Brompton NHS Foundation Trust and Imperial College London, London, United Kingdom
⨯
Colin J. Clarke,

Affiliation Airway Disease Section, National Heart & Lung Institute, NIHR Respiratory Biomedical Research Unit at the Royal Brompton NHS Foundation Trust and Imperial College London, London, United Kingdom
⨯
Andrew L. Durham,

Affiliation Airway Disease Section, National Heart & Lung Institute, NIHR Respiratory Biomedical Research Unit at the Royal Brompton NHS Foundation Trust and Imperial College London, London, United Kingdom
⨯
Patrick Mallia,

Affiliation Airway Disease Infection Section, National Heart & Lung Institute, Imperial College London, London, United Kingdom
⨯
Joseph Footitt †,

† Deceased.

Affiliation Airway Disease Infection Section, National Heart & Lung Institute, Imperial College London, London, United Kingdom
⨯
Sebastian L. Johnston,

Affiliation Airway Disease Infection Section, National Heart & Lung Institute, Imperial College London, London, United Kingdom
⨯
Peter J. Barnes,

Affiliation Airway Disease Section, National Heart & Lung Institute, NIHR Respiratory Biomedical Research Unit at the Royal Brompton NHS Foundation Trust and Imperial College London, London, United Kingdom
⨯
Simon R. Hall,

Affiliation RRI DPU, GlaxoSmithKline, Stevenage, United Kingdom
⨯
Karen D. Simpson,

Affiliation RRI DPU, GlaxoSmithKline, Stevenage, United Kingdom
⨯
Malcolm R. Starkey,

Affiliation Priority Research Centre for Respiratory Diseases, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia
⨯
Philip M. Hansbro,

Affiliation Priority Research Centre for Respiratory Diseases, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia
⨯
Ian M. Adcock,

Affiliation Airway Disease Section, National Heart & Lung Institute, NIHR Respiratory Biomedical Research Unit at the Royal Brompton NHS Foundation Trust and Imperial College London, London, United Kingdom
⨯
Coen H. Wiegman

* E-mail: c.wiegman@imperial.ac.uk

Affiliation Airway Disease Section, National Heart & Lung Institute, NIHR Respiratory Biomedical Research Unit at the Royal Brompton NHS Foundation Trust and Imperial College London, London, United Kingdom
⨯

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD

Kirsty E. Russell,
Kian Fan Chung,
Colin J. Clarke,
Andrew L. Durham,
Patrick Mallia,
Joseph Footitt,
Sebastian L. Johnston,
Peter J. Barnes,
Simon R. Hall,
Karen D. Simpson

Published: January 11, 2016
https://doi.org/10.1371/journal.pone.0146102

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