Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia

Open Access

Peer-reviewed

Research Article

Shimpei Otsuka,

Affiliation Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B47 Nagatsuta-cho, Midori-ku, Yokohama 226–8501, Japan
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Kentaro Matsumoto,

Affiliation Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B47 Nagatsuta-cho, Midori-ku, Yokohama 226–8501, Japan
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Motowo Nakajima,

Affiliation SBI pharmaceuticals CO., LTD., Izumi Garden Tower 20F, 1-6-1, Roppongi, Minato-ku, Tokyo, 106–6020, Japan
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Tohru Tanaka,

Affiliation SBI pharmaceuticals CO., LTD., Izumi Garden Tower 20F, 1-6-1, Roppongi, Minato-ku, Tokyo, 106–6020, Japan
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Shun-ichiro Ogura

* E-mail: sogura@bio.titech.ac.jp

Affiliation Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B47 Nagatsuta-cho, Midori-ku, Yokohama 226–8501, Japan
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Hypoxia
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Porphyrins
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Biosynthesis
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Mitochondria
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Medical hypoxia
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Oxygen
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Excretion
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Gastric cancer
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