Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Hai-Ha Le; Chadia El-Khatib; Margaux Mombled; Frédéric Guitarian; Muaamar Al-Gobari; Mor Fall; Perrine Janiaud; Ivanny Marchant; Michel Cucherat; Théodora Bejan-Angoulvant; François Gueyffier

doi:10.1371/journal.pone.0145958

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Open Access

Peer-reviewed

Research Article

Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Hai-Ha Le,

Affiliation Laboratoire de Biologie et Biométrie Evolutive - Equipe Modélisation des Effets Thérapeutiques, UMR 5558 Université Claude Bernard Lyon1, Lyon, France
⨯
Chadia El-Khatib,

Affiliation Laboratoire de Biologie et Biométrie Evolutive - Equipe Modélisation des Effets Thérapeutiques, UMR 5558 Université Claude Bernard Lyon1, Lyon, France
⨯
Margaux Mombled,

Affiliation Laboratoire de Biologie et Biométrie Evolutive - Equipe Modélisation des Effets Thérapeutiques, UMR 5558 Université Claude Bernard Lyon1, Lyon, France
⨯
Frédéric Guitarian,

Affiliation Laboratoire de Biologie et Biométrie Evolutive - Equipe Modélisation des Effets Thérapeutiques, UMR 5558 Université Claude Bernard Lyon1, Lyon, France
⨯
Muaamar Al-Gobari,

Affiliation Lausanne University Hospital (CHUV), Institute of social & preventive medicine (IUMSP), Lausanne, Switzerland
⨯
Mor Fall,

Affiliation Laboratoire de Biologie et Biométrie Evolutive - Equipe Modélisation des Effets Thérapeutiques, UMR 5558 Université Claude Bernard Lyon1, Lyon, France
⨯
Perrine Janiaud,

Affiliation Laboratoire de Biologie et Biométrie Evolutive - Equipe Modélisation des Effets Thérapeutiques, UMR 5558 Université Claude Bernard Lyon1, Lyon, France
⨯
Ivanny Marchant,

Affiliation Escuela de Medicina, Departamento de Pre-clínicas, Universidad de Valparaíso, Valparaíso, Chile
⨯
Michel Cucherat,

Affiliation Laboratoire de Biologie et Biométrie Evolutive - Equipe Modélisation des Effets Thérapeutiques, UMR 5558 Université Claude Bernard Lyon1, Lyon, France
⨯
Théodora Bejan-Angoulvant,

Affiliations CHRU de Tours, Service de Pharmacologie Clinique, Hôpital Bretonneau, Tours, France, CNRS UMR 7292, Tours, France, Université François-Rabelais, GICC, Tours, France
⨯
François Gueyffier

* E-mail: francois.gueyffier@univ-lyon1.fr

Affiliations Laboratoire de Biologie et Biométrie Evolutive - Equipe Modélisation des Effets Thérapeutiques, UMR 5558 Université Claude Bernard Lyon1, Lyon, France, Service de Pharmacologie Clinique et essais thérapeutiques, Hospices Civils de Lyon, Lyon, France
⨯

Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Hai-Ha Le,
Chadia El-Khatib,
Margaux Mombled,
Frédéric Guitarian,
Muaamar Al-Gobari,
Mor Fall,
Perrine Janiaud,
Ivanny Marchant,
Michel Cucherat,
Théodora Bejan-Angoulvant

Published: February 18, 2016
https://doi.org/10.1371/journal.pone.0145958

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Aldosterone
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Myocardial infarction
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Death rates
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