Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats

Beatriz Martín-Fernández; Alfonso Rubio-Navarro; Isabel Cortegano; Sandra Ballesteros; Mario Alía; Pablo Cannata-Ortiz; Elena Olivares-Álvaro; Jesús Egido; Belén de Andrés; María Luisa Gaspar; Natalia de las Heras; Vicente Lahera; Juan Antonio Moreno

doi:10.1371/journal.pone.0145946

Loading metrics

Open Access

Peer-reviewed

Research Article

Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats

Beatriz Martín-Fernández ,

* E-mail: bmartinfernandez@med.ucm.es (BMF); jamoreno@fjd.es (JAM)

Affiliation Department of Physiology, Faculty of Medicine, Complutense University, 28040, Madrid, Spain
⨯
Alfonso Rubio-Navarro,

Affiliation Renal, Vascular and Diabetes Research Lab, IIS-Fundación Jiménez Díaz, Autonoma University (UAM), 28040, Madrid, Spain
⨯
Isabel Cortegano,

Affiliation Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda, 28220, Madrid, Spain
⨯
Sandra Ballesteros,

Affiliation Department of Physiology, Faculty of Medicine, Complutense University, 28040, Madrid, Spain
⨯
Mario Alía,

Affiliation Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda, 28220, Madrid, Spain
⨯
Pablo Cannata-Ortiz,

Affiliation Department of Pathology, IIS-Fundación Jiménez Díaz, Autonoma University (UAM), 28040, Madrid, Spain
⨯
Elena Olivares-Álvaro,

Affiliation Department of Physiology, Faculty of Medicine, Complutense University, 28040, Madrid, Spain
⨯
Jesús Egido,

Affiliation Renal, Vascular and Diabetes Research Lab, IIS-Fundación Jiménez Díaz, Autonoma University (UAM), 28040, Madrid, Spain
⨯
Belén de Andrés,

Affiliation Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda, 28220, Madrid, Spain
⨯
María Luisa Gaspar,

Affiliation Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda, 28220, Madrid, Spain
⨯
Natalia de las Heras,

Affiliation Department of Physiology, Faculty of Medicine, Complutense University, 28040, Madrid, Spain
⨯
Vicente Lahera,

Affiliation Department of Physiology, Faculty of Medicine, Complutense University, 28040, Madrid, Spain
⨯
Juan Antonio Moreno

* E-mail: bmartinfernandez@med.ucm.es (BMF); jamoreno@fjd.es (JAM)

Affiliation Renal, Vascular and Diabetes Research Lab, IIS-Fundación Jiménez Díaz, Autonoma University (UAM), 28040, Madrid, Spain
⨯

Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats

Beatriz Martín-Fernández,
Alfonso Rubio-Navarro,
Isabel Cortegano,
Sandra Ballesteros,
Mario Alía,
Pablo Cannata-Ortiz,
Elena Olivares-Álvaro,
Jesús Egido,
Belén de Andrés,
María Luisa Gaspar

Published: January 5, 2016
https://doi.org/10.1371/journal.pone.0145946

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Aldosterone
Is the Subject Area "Aldosterone" applicable to this article?

Thanks for your feedback.
Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Fibrosis
Is the Subject Area "Fibrosis" applicable to this article?

Thanks for your feedback.
Liposomes
Is the Subject Area "Liposomes" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Blood pressure
Is the Subject Area "Blood pressure" applicable to this article?

Thanks for your feedback.
Collagens
Is the Subject Area "Collagens" applicable to this article?

Thanks for your feedback.