Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

Fabian Jacob; Amina Y. Yonis; Friederike Cuello; Pradeep Luther; Thomas Schulze; Alexandra Eder; Thomas Streichert; Ingra Mannhardt; Marc N. Hirt; Sebastian Schaaf; Justus Stenzig; Thomas Force; Thomas Eschenhagen; Arne Hansen

doi:10.1371/journal.pone.0145937

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Peer-reviewed

Research Article

Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

Fabian Jacob ,

Contributed equally to this work with: Fabian Jacob, Amina Y. Yonis, Thomas Eschenhagen, Arne Hansen

Affiliation Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
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Amina Y. Yonis ,

Contributed equally to this work with: Fabian Jacob, Amina Y. Yonis, Thomas Eschenhagen, Arne Hansen

Affiliation Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Friederike Cuello,

Affiliation Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
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Pradeep Luther,

Affiliation Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
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Thomas Schulze,

Affiliation Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
⨯
Alexandra Eder,

Affiliation Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
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Thomas Streichert,

Current address: Department of Clinical Chemistry, University Hospital of Cologne, Cologne, Germany

Affiliation Department of Clinical Chemistry/Central Laboratories, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Ingra Mannhardt,

Affiliation Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
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Marc N. Hirt,

Affiliation Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
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Sebastian Schaaf,

Affiliation Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
⨯
Justus Stenzig,

Affiliation Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
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Thomas Force,

Affiliation Center for Translational Medicine, Cardiology Division, Temple University School of Medicine, Philadelphia, Pennsylvania, 19140, United States of America
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Thomas Eschenhagen ,

Contributed equally to this work with: Fabian Jacob, Amina Y. Yonis, Thomas Eschenhagen, Arne Hansen

Affiliation Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
⨯
Arne Hansen

Contributed equally to this work with: Fabian Jacob, Amina Y. Yonis, Thomas Eschenhagen, Arne Hansen

* E-mail: ar.hansen@uke.de

Affiliation Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
⨯

Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

Fabian Jacob,
Amina Y. Yonis,
Friederike Cuello,
Pradeep Luther,
Thomas Schulze,
Alexandra Eder,
Thomas Streichert,
Ingra Mannhardt,
Marc N. Hirt,
Sebastian Schaaf

Published: February 3, 2016
https://doi.org/10.1371/journal.pone.0145937

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