Comparing Residue Clusters from Thermophilic and Mesophilic Enzymes Reveals Adaptive Mechanisms

Open Access

Peer-reviewed

Research Article

Deanne W. Sammond,

Affiliation Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado, 80401, United States of America
⨯
Noah Kastelowitz,

Affiliation Department of Chemistry & Biochemistry and the BioFrontiers Institute, University of Colorado, Boulder, Colorado, 80309, United States of America
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Michael E. Himmel,

Affiliation Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado, 80401, United States of America
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Hang Yin,

Affiliation Department of Chemistry & Biochemistry and the BioFrontiers Institute, University of Colorado, Boulder, Colorado, 80309, United States of America
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Michael F. Crowley,

Affiliation Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado, 80401, United States of America
⨯
Yannick J. Bomble

* E-mail: Yannick.Bomble@nrel.gov

Affiliation Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado, 80401, United States of America
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Sequence motif analysis
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Enzyme structure
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Protein structure comparison
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Bacillus
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Dehydrogenases
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Sequence alignment
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Epistasis
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Protein structure databases
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