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Open Access

Peer-reviewed

Research Article

Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia

Ying Xin,

Affiliations Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China, Department of Pediatrics, Division of Endocrinology, University of Louisville, Wendy L. Novak Diabetes Care Center, Louisville, Kentucky, United States of America
⨯
Xin Jiang,

Affiliation Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, China
⨯
Yishu Wang,

Affiliation Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China
⨯
Xuejin Su,

Affiliation Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China
⨯
Meiyu Sun,

Affiliation Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China
⨯
Lihong Zhang,

Affiliation Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China
⨯
Yi Tan,

Affiliation Department of Pediatrics, Division of Endocrinology, University of Louisville, Wendy L. Novak Diabetes Care Center, Louisville, Kentucky, United States of America
⨯
Kupper A. Wintergerst,

Affiliation Department of Pediatrics, Division of Endocrinology, University of Louisville, Wendy L. Novak Diabetes Care Center, Louisville, Kentucky, United States of America
⨯
Yan Li ,

* E-mail: Yan.Li@ki.se (Yan Li); ylli_jlu@126.com (Yulin Li)

Affiliation Department of Orthopedic Surgery, Karolinska University Hospital, Stockholm, Sweden
⨯
Yulin Li

* E-mail: Yan.Li@ki.se (Yan Li); ylli_jlu@126.com (Yulin Li)

Affiliation Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China
⨯

Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia

Ying Xin,
Xin Jiang,
Yishu Wang,
Xuejin Su,
Meiyu Sun,
Lihong Zhang,
Yi Tan,
Kupper A. Wintergerst,
Yan Li,
Yulin Li

x

Published: January 12, 2016
https://doi.org/10.1371/journal.pone.0145838

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Cell differentiation
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Insulin
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Glucose
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Diabetes mellitus
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Mesenchymal stem cells
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Renal transplantation
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Apoptosis
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Immunofluorescence staining
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