The Impact and Cost-Effectiveness of a Four-Month Regimen for First-Line Treatment of Active Tuberculosis in South Africa

Gwenan M. Knight; Gabriela B. Gomez; Peter J. Dodd; David Dowdy; Alice Zwerling; William A. Wells; Frank Cobelens; Anna Vassall; Richard G. White

doi:10.1371/journal.pone.0145796

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Open Access

Peer-reviewed

Research Article

The Impact and Cost-Effectiveness of a Four-Month Regimen for First-Line Treatment of Active Tuberculosis in South Africa

Gwenan M. Knight ,

* E-mail: g.knight@imperial.ac.uk

Current address: Imperial College London, London, United Kingdom

Affiliation Centre for Mathematical Modelling of Infectious Diseases, TB Centre, TB Modeling Group, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Gabriela B. Gomez,

Affiliations Amsterdam Institute for Global Health and Development and Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Peter J. Dodd,

Affiliation School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom
⨯
David Dowdy,

Affiliation Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America
⨯
Alice Zwerling,

Affiliation Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America
⨯
William A. Wells,

Current address: United States Agency for International Development, Washington DC, United States of America

Affiliation Global Alliance for TB Drug Development, New York, United States of America
⨯
Frank Cobelens,

Affiliations Amsterdam Institute for Global Health and Development and Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, KNCV Tuberculosis Foundation, The Hague, The Netherlands
⨯
Anna Vassall,

Affiliation Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Richard G. White

Affiliation Centre for Mathematical Modelling of Infectious Diseases, TB Centre, TB Modeling Group, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯

The Impact and Cost-Effectiveness of a Four-Month Regimen for First-Line Treatment of Active Tuberculosis in South Africa

Gwenan M. Knight,
Gabriela B. Gomez,
Peter J. Dodd,
David Dowdy,
Alice Zwerling,
William A. Wells,
Frank Cobelens,
Anna Vassall,
Richard G. White

Published: December 30, 2015
https://doi.org/10.1371/journal.pone.0145796

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Tuberculosis
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HIV
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South Africa
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Treatment guidelines
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Cost-effectiveness analysis
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Mycobacterium tuberculosis
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Multi-drug-resistant tuberculosis
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