Freeze and Thaw of CD4+CD25+Foxp3+ Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host Disease

Mareike Florek; Dominik Schneidawind; Antonio Pierini; Jeanette Baker; Randall Armstrong; Yuqiong Pan; Dennis Leveson-Gower; Robert Negrin; Everett Meyer

doi:10.1371/journal.pone.0145763

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Peer-reviewed

Research Article

Freeze and Thaw of CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host Disease

Mareike Florek ,

Contributed equally to this work with: Mareike Florek, Dominik Schneidawind

Affiliation Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America
⨯
Dominik Schneidawind ,

Contributed equally to this work with: Mareike Florek, Dominik Schneidawind

* E-mail: dominik.schneidawind@med.uni-tuebingen.de

Affiliations Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America, Department of Medicine II, Eberhard Karls University, Tübingen, Germany
⨯
Antonio Pierini,

Affiliations Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America, Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy
⨯
Jeanette Baker,

Affiliation Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America
⨯
Randall Armstrong,

Affiliation Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America
⨯
Yuqiong Pan,

Affiliation Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America
⨯
Dennis Leveson-Gower,

Affiliation Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America
⨯
Robert Negrin,

Affiliation Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America
⨯
Everett Meyer

Affiliation Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America
⨯

Freeze and Thaw of CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host Disease

Mareike Florek,
Dominik Schneidawind,
Antonio Pierini,
Jeanette Baker,
Randall Armstrong,
Yuqiong Pan,
Dennis Leveson-Gower,
Robert Negrin,
Everett Meyer

Published: December 22, 2015
https://doi.org/10.1371/journal.pone.0145763

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