Stable Human Hepatoma Cell Lines for Efficient Regulated Expression of Nucleoside/Nucleotide Analog Resistant and Vaccine Escape Hepatitis B Virus Variants and Woolly Monkey Hepatitis B Virus

Xin Cheng; Weiwei Guan; Shuo Sun; Baosheng Li; Haijun Li; Fubiao Kang; Jiwen Kang; Dongliang Yang; Michael Nassal; Dianxing Sun

doi:10.1371/journal.pone.0145746

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Peer-reviewed

Research Article

Stable Human Hepatoma Cell Lines for Efficient Regulated Expression of Nucleoside/Nucleotide Analog Resistant and Vaccine Escape Hepatitis B Virus Variants and Woolly Monkey Hepatitis B Virus

Xin Cheng ,

Contributed equally to this work with: Xin Cheng, Weiwei Guan, Shuo Sun

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Weiwei Guan ,

Contributed equally to this work with: Xin Cheng, Weiwei Guan, Shuo Sun

Current address: The Fifth Hospital of Shijiazhuang City, Shijiazhuang, Hebei, China

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Shuo Sun ,

Contributed equally to this work with: Xin Cheng, Weiwei Guan, Shuo Sun

Affiliations The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China, Troop 66220 of PLA, Xingtai of Hebei Province, PR China
⨯
Baosheng Li,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Haijun Li,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Fubiao Kang,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Jiwen Kang,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Dongliang Yang,

Affiliation Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
⨯
Michael Nassal ,

* E-mail: nassal2@ukl.uni-freiburg.de (MN); sundianxing@hotmail.com (SD)

¶‡ These authors also contributed equally to this work.

Affiliation Department of Internal Medicine II / Molecular Biology, University Hospital Freiburg, Freiburg, Germany
⨯
Dianxing Sun

* E-mail: nassal2@ukl.uni-freiburg.de (MN); sundianxing@hotmail.com (SD)

¶‡ These authors also contributed equally to this work.

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯

Stable Human Hepatoma Cell Lines for Efficient Regulated Expression of Nucleoside/Nucleotide Analog Resistant and Vaccine Escape Hepatitis B Virus Variants and Woolly Monkey Hepatitis B Virus

Xin Cheng,
Weiwei Guan,
Shuo Sun,
Baosheng Li,
Haijun Li,
Fubiao Kang,
Jiwen Kang,
Dongliang Yang,
Michael Nassal,
Dianxing Sun

Published: December 23, 2015
https://doi.org/10.1371/journal.pone.0145746

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