Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation

Open Access

Peer-reviewed

Research Article

Evan M. Green,

Current address: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

Affiliation Vollum Institute, Oregon Health & Science University, Portland, Oregon, United States of America
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Jonathan A. Coleman,

Affiliation Vollum Institute, Oregon Health & Science University, Portland, Oregon, United States of America
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Eric Gouaux

* E-mail: gouauxe@ohsu.edu

Affiliations Vollum Institute, Oregon Health & Science University, Portland, Oregon, United States of America, Howard Hughes Medical Institute, Oregon Health & Science University, Portland, Oregon, United States of America
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Serotonin
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Detergents
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Point mutation
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Drug screening
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High throughput screening
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Melting
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Crystal structure
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Protein structure determination
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