Synthesis of a Vpr-Binding Derivative for Use as a Novel HIV-1 Inhibitor

Kyoji Hagiwara; Hideki Ishii; Tomoyuki Murakami; Shin-nosuke Takeshima; Nopporn Chutiwitoonchai; Eiichi N. Kodama; Kumi Kawaji; Yasumitsu Kondoh; Kaori Honda; Hiroyuki Osada; Yasuko Tsunetsugu-Yokota; Masaaki Suzuki; Yoko Aida

doi:10.1371/journal.pone.0145573

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Open Access

Peer-reviewed

Research Article

Synthesis of a Vpr-Binding Derivative for Use as a Novel HIV-1 Inhibitor

Kyoji Hagiwara,

Affiliation Viral Infectious Diseases Unit, RIKEN, 2–1 Hirosawa, Wako, Saitama 351–0198, Japan
⨯
Hideki Ishii,

Affiliation Molecular Imaging Medicinal Chemistry Laboratory, RIKEN Center for Molecular Imaging Science, 6-7-3 Minatoshima-minamimachi, Chuo-ku, Kobe, Hyogo 650–0047, Japan
⨯
Tomoyuki Murakami,

Affiliation Viral Infectious Diseases Unit, RIKEN, 2–1 Hirosawa, Wako, Saitama 351–0198, Japan
⨯
Shin-nosuke Takeshima,

Affiliation Viral Infectious Diseases Unit, RIKEN, 2–1 Hirosawa, Wako, Saitama 351–0198, Japan
⨯
Nopporn Chutiwitoonchai,

Affiliation Viral Infectious Diseases Unit, RIKEN, 2–1 Hirosawa, Wako, Saitama 351–0198, Japan
⨯
Eiichi N. Kodama,

Affiliation Division of Miyagi Community Health Promotion, Tohoku University Graduate School of Medicine, 2–1 Seiryocho, Aoba-ku, Sendai 980–8575, Japan
⨯
Kumi Kawaji,

Affiliation Division of Miyagi Community Health Promotion, Tohoku University Graduate School of Medicine, 2–1 Seiryocho, Aoba-ku, Sendai 980–8575, Japan
⨯
Yasumitsu Kondoh,

Affiliation Chemical Biology Research Group, RIKEN CSRS, 2–1 Hirosawa, Wako, Saitama 351–0198, Japan
⨯
Kaori Honda,

Affiliation Chemical Biology Research Group, RIKEN CSRS, 2–1 Hirosawa, Wako, Saitama 351–0198, Japan
⨯
Hiroyuki Osada,

Affiliation Chemical Biology Research Group, RIKEN CSRS, 2–1 Hirosawa, Wako, Saitama 351–0198, Japan
⨯
Yasuko Tsunetsugu-Yokota,

Affiliation Department of Frontier Biosciences, Department of Immunology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162–8640, Japan
⨯
Masaaki Suzuki,

Affiliation Molecular Imaging Medicinal Chemistry Laboratory, RIKEN Center for Molecular Imaging Science, 6-7-3 Minatoshima-minamimachi, Chuo-ku, Kobe, Hyogo 650–0047, Japan
⨯
Yoko Aida

* E-mail: aida@riken.jp

Affiliation Viral Infectious Diseases Unit, RIKEN, 2–1 Hirosawa, Wako, Saitama 351–0198, Japan
⨯

Synthesis of a Vpr-Binding Derivative for Use as a Novel HIV-1 Inhibitor

Kyoji Hagiwara,
Hideki Ishii,
Tomoyuki Murakami,
Shin-nosuke Takeshima,
Nopporn Chutiwitoonchai,
Eiichi N. Kodama,
Kumi Kawaji,
Yasumitsu Kondoh,
Kaori Honda,
Hiroyuki Osada

Published: December 23, 2015
https://doi.org/10.1371/journal.pone.0145573

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