Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus

Guangyu Zhao; Yuting Jiang; Hongjie Qiu; Tongtong Gao; Yang Zeng; Yan Guo; Hong Yu; Junfeng Li; Zhihua Kou; Lanying Du; Wenjie Tan; Shibo Jiang; Shihui Sun; Yusen Zhou

doi:10.1371/journal.pone.0145561

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Open Access

Peer-reviewed

Research Article

Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus

Guangyu Zhao ,

Contributed equally to this work with: Guangyu Zhao, Yuting Jiang

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯
Yuting Jiang ,

Contributed equally to this work with: Guangyu Zhao, Yuting Jiang

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯
Hongjie Qiu,

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯
Tongtong Gao,

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯
Yang Zeng,

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯
Yan Guo,

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯
Hong Yu,

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯
Junfeng Li,

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯
Zhihua Kou,

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯
Lanying Du,

Affiliation Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, 10065, United States of America
⨯
Wenjie Tan,

Affiliation Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China
⨯
Shibo Jiang,

Affiliations Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, 10065, United States of America, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai, 200433, China
⨯
Shihui Sun ,

* E-mail: yszhou@bmi.ac.cn (Y. Zhou); sunsh01@163.com (SS)

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯
Yusen Zhou

* E-mail: yszhou@bmi.ac.cn (Y. Zhou); sunsh01@163.com (SS)

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
⨯

Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus

Guangyu Zhao,
Yuting Jiang,
Hongjie Qiu,
Tongtong Gao,
Yang Zeng,
Yan Guo,
Hong Yu,
Junfeng Li,
Zhihua Kou,
Lanying Du

Published: December 23, 2015
https://doi.org/10.1371/journal.pone.0145561

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