Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner

• Chunqiu Chen ,

  Contributed equally to this work with: Chunqiu Chen, Meiling Lu

  Affiliation Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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• Meiling Lu ,

  Contributed equally to this work with: Chunqiu Chen, Meiling Lu

  Affiliation Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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• Qiuhui Pan,

  Affiliation Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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• Jakub Fichna ,

  * E-mail: jakub.fichna@umed.lodz.pl

  Affiliation Department of Biochemistry, Medical University of Lodz, Lodz, Poland

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• Lijun Zheng,

  Affiliation Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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• Kesheng Wang,

  Affiliation Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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• Zhen Yu,

  Affiliation Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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• Yongyu Li,

  Affiliation Department of Pathophysiology, Institute of Digestive Disease, Tongji University School of Medicine, Shanghai, China

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• Kun Li,

  Affiliation Department of Pathophysiology, Institute of Digestive Disease, Tongji University School of Medicine, Shanghai, China

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• Aihong Song,

  Affiliation Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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• Zhongchen Liu,

  Affiliation Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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• Zhenshun Song,

  Affiliation Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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• Martin Kreis

  Affiliation Charité University Medicine, Department of General-, Visceral- and Vascular Surgery, Campus Benjamin Franklin, Berlin, Germany

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