Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models

Deepak K. Rajpal; Jean-Louis Klein; David Mayhew; Joyce Boucheron; Aaron T. Spivak; Vinod Kumar; Karen Ingraham; Mark Paulik; Lihong Chen; Stephanie Van Horn; Elizabeth Thomas; Ganesh Sathe; George P. Livi; David J. Holmes; James R. Brown

doi:10.1371/journal.pone.0145499

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Open Access

Peer-reviewed

Research Article

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models

Deepak K. Rajpal,

Affiliation Computational Biology, Target Sciences, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Jean-Louis Klein,

Affiliation Target and Pathway Validation, Target Sciences, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
David Mayhew,

Affiliation Computational Biology, Target Sciences, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Joyce Boucheron,

Affiliation Enteroendocrine Discovery Performance Unit, Research and Development, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America
⨯
Aaron T. Spivak,

Affiliation Computational Biology, Target Sciences, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Vinod Kumar,

Affiliation Computational Biology, Target Sciences, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Karen Ingraham,

Affiliation Antibacterial Discovery Performance Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Mark Paulik,

Current address: Intarcia Therapeutics, Inc., Research Triangle Park, North Carolina, United States of America

Affiliation Enteroendocrine Discovery Performance Unit, Research and Development, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America
⨯
Lihong Chen,

Affiliation Enteroendocrine Discovery Performance Unit, Research and Development, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America
⨯
Stephanie Van Horn,

Affiliation Target and Pathway Validation, Target Sciences, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Elizabeth Thomas,

Affiliation Target and Pathway Validation, Target Sciences, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Ganesh Sathe,

Affiliation Target and Pathway Validation, Target Sciences, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
George P. Livi,

Affiliation Target and Pathway Validation, Target Sciences, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
David J. Holmes,

Affiliation Antibacterial Discovery Performance Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
James R. Brown

* E-mail: James.R.Brown@gsk.com

Affiliation Computational Biology, Target Sciences, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models

Deepak K. Rajpal,
Jean-Louis Klein,
David Mayhew,
Joyce Boucheron,
Aaron T. Spivak,
Vinod Kumar,
Karen Ingraham,
Mark Paulik,
Lihong Chen,
Stephanie Van Horn

Published: December 28, 2015
https://doi.org/10.1371/journal.pone.0145499

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