A Novel Admixture-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics

Jorge Duconge; Alga S. Ramos; Karla Claudio-Campos; Giselle Rivera-Miranda; Luis Bermúdez-Bosch; Jessicca Y. Renta; Carmen L. Cadilla; Iadelisse Cruz; Juan F. Feliu; Cunegundo Vergara; Gualberto Ruaño

doi:10.1371/journal.pone.0145480

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Open Access

Peer-reviewed

Research Article

A Novel Admixture-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics

Jorge Duconge ,

Contributed equally to this work with: Jorge Duconge, Alga S. Ramos

* E-mail: Jorge.duconge@upr.edu

Affiliation Pharmaceutical Sciences Department, School of Pharmacy, University of Puerto Rico Medical Sciences Campus (UPR-MSC), San Juan, Puerto Rico, United States of America
⨯
Alga S. Ramos ,

Contributed equally to this work with: Jorge Duconge, Alga S. Ramos

Affiliation Pharmaceutical Sciences Department, School of Pharmacy, University of Puerto Rico Medical Sciences Campus (UPR-MSC), San Juan, Puerto Rico, United States of America
⨯
Karla Claudio-Campos,

Affiliation Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico Medical Sciences Campus (UPR-MSC), San Juan, Puerto Rico, United States of America
⨯
Giselle Rivera-Miranda,

Affiliation Pharmacy Service, VA Caribbean Healthcare Systems (VACHS), San Juan, Puerto Rico, United States of America
⨯
Luis Bermúdez-Bosch,

Affiliation Pharmaceutical Sciences Department, School of Pharmacy, University of Puerto Rico Medical Sciences Campus (UPR-MSC), San Juan, Puerto Rico, United States of America
⨯
Jessicca Y. Renta,

Affiliation Molecular Genetics Lab, Department of Biochemistry, School of Medicine, University of Puerto Rico Medical Sciences Campus (UPR-MSC), San Juan, Puerto Rico, United States of America
⨯
Carmen L. Cadilla,

Affiliation Molecular Genetics Lab, Department of Biochemistry, School of Medicine, University of Puerto Rico Medical Sciences Campus (UPR-MSC), San Juan, Puerto Rico, United States of America
⨯
Iadelisse Cruz,

Affiliation Pharmaceutical Sciences Department, School of Pharmacy, University of Puerto Rico Medical Sciences Campus (UPR-MSC), San Juan, Puerto Rico, United States of America
⨯
Juan F. Feliu,

Affiliation Pharmacy Service, VA Caribbean Healthcare Systems (VACHS), San Juan, Puerto Rico, United States of America
⨯
Cunegundo Vergara,

Affiliation Brownstone Outpatient Clinic, Hartford Hospital, Hartford, CT, United States of America
⨯
Gualberto Ruaño

Affiliation Genomas Inc., Hartford, CT, United States of America
⨯

A Novel Admixture-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics

Jorge Duconge,
Alga S. Ramos,
Karla Claudio-Campos,
Giselle Rivera-Miranda,
Luis Bermúdez-Bosch,
Jessicca Y. Renta,
Carmen L. Cadilla,
Iadelisse Cruz,
Juan F. Feliu,
Cunegundo Vergara

Published: January 8, 2016
https://doi.org/10.1371/journal.pone.0145480

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