Modeling-Enabled Characterization of Novel NLRX1 Ligands

Pinyi Lu; Raquel Hontecillas; Vida Abedi; Shiv Kale; Andrew Leber; Chase Heltzel; Mark Langowski; Victoria Godfrey; Casandra Philipson; Nuria Tubau-Juni; Adria Carbo; Stephen Girardin; Aykut Uren; Josep Bassaganya-Riera

doi:10.1371/journal.pone.0145420

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Open Access

Peer-reviewed

Research Article

Modeling-Enabled Characterization of Novel NLRX1 Ligands

Pinyi Lu,

Affiliations The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America, Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America
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Raquel Hontecillas,

Affiliations The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America, Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America
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Vida Abedi,

Affiliations The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America, Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America
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Shiv Kale,

Affiliations The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America, Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America
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Andrew Leber,

Affiliations The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America, Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America
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Chase Heltzel,

Affiliations The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America, Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America
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Mark Langowski,

Affiliations The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America, Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America
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Victoria Godfrey,

Affiliations The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America, Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America
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Casandra Philipson,

Affiliation BioTherapeutics, 1800 Kraft Drive, Suite 200, Blacksburg, Virginia, 24060, United States of America
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Nuria Tubau-Juni,

Affiliations The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America, Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America
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Adria Carbo,

Affiliation BioTherapeutics, 1800 Kraft Drive, Suite 200, Blacksburg, Virginia, 24060, United States of America
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Stephen Girardin,

Affiliation Laboratory of Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada
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Aykut Uren,

Affiliation Georgetown University Medical Center, Washington, District of Columbia, 20057, United States of America
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Josep Bassaganya-Riera

* E-mail: jbassaga@vt.edu

Affiliations The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America, Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America
⨯

Modeling-Enabled Characterization of Novel NLRX1 Ligands

Pinyi Lu,
Raquel Hontecillas,
Vida Abedi,
Shiv Kale,
Andrew Leber,
Chase Heltzel,
Mark Langowski,
Victoria Godfrey,
Casandra Philipson,
Nuria Tubau-Juni

Published: December 29, 2015
https://doi.org/10.1371/journal.pone.0145420

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