Differential Toll-Like Receptor-Signalling of Burkholderia pseudomallei Lipopolysaccharide in Murine and Human Models

Tassili A. F. Weehuizen; Joann L. Prior; Thomas W. van der Vaart; Sarah A. Ngugi; Sergey A. Nepogodiev; Robert A. Field; Liesbeth M. Kager; Cornelis van ‘t Veer; Alex F. de Vos; W. Joost Wiersinga

doi:10.1371/journal.pone.0145397

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Open Access

Peer-reviewed

Research Article

Differential Toll-Like Receptor-Signalling of Burkholderia pseudomallei Lipopolysaccharide in Murine and Human Models

Tassili A. F. Weehuizen ,

* E-mail: t.a.weehuizen@amc.uva.nl (TAFW); w.j.wiersinga@amc.uva.nl (WJW)

Affiliations Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, the Netherlands
⨯
Joann L. Prior,

Affiliation Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom
⨯
Thomas W. van der Vaart,

Affiliations Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, the Netherlands
⨯
Sarah A. Ngugi,

Affiliation Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom
⨯
Sergey A. Nepogodiev,

Affiliation John Innes Centre, Norwich Research Park, Colney, United Kingdom
⨯
Robert A. Field,

Affiliation John Innes Centre, Norwich Research Park, Colney, United Kingdom
⨯
Liesbeth M. Kager,

Affiliations Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, the Netherlands
⨯
Cornelis van ‘t Veer,

Affiliations Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, the Netherlands
⨯
Alex F. de Vos,

Affiliations Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, the Netherlands
⨯
W. Joost Wiersinga

* E-mail: t.a.weehuizen@amc.uva.nl (TAFW); w.j.wiersinga@amc.uva.nl (WJW)

Affiliations Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, the Netherlands, Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, Amsterdam, the Netherlands
⨯

Differential Toll-Like Receptor-Signalling of Burkholderia pseudomallei Lipopolysaccharide in Murine and Human Models

Tassili A. F. Weehuizen,
Joann L. Prior,
Thomas W. van der Vaart,
Sarah A. Ngugi,
Sergey A. Nepogodiev,
Robert A. Field,
Liesbeth M. Kager,
Cornelis van ‘t Veer,
Alex F. de Vos,
W. Joost Wiersinga

Published: December 21, 2015
https://doi.org/10.1371/journal.pone.0145397

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