Protection against H5N1 Influenza Virus Induced by Matrix-M Adjuvanted Seasonal Virosomal Vaccine in Mice Requires Both Antibodies and T Cells

Freek Cox; Matthijs Baart; Jeroen Huizingh; Jeroen Tolboom; Liesbeth Dekking; Jaap Goudsmit; Eirikur Saeland; Katarina Radošević

doi:10.1371/journal.pone.0145243

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Peer-reviewed

Research Article

Protection against H5N1 Influenza Virus Induced by Matrix-M Adjuvanted Seasonal Virosomal Vaccine in Mice Requires Both Antibodies and T Cells

Freek Cox,

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Matthijs Baart,

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Jeroen Huizingh,

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Jeroen Tolboom,

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Liesbeth Dekking,

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Jaap Goudsmit,

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Eirikur Saeland ,

* E-mail: Esaeland@its.jnj.com

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Katarina Radošević

Current address: Sanofi, Global Biotherapeutics, Vitry-sur-Seine, France

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯

Protection against H5N1 Influenza Virus Induced by Matrix-M Adjuvanted Seasonal Virosomal Vaccine in Mice Requires Both Antibodies and T Cells

Freek Cox,
Matthijs Baart,
Jeroen Huizingh,
Jeroen Tolboom,
Liesbeth Dekking,
Jaap Goudsmit,
Eirikur Saeland,
Katarina Radošević

Published: December 22, 2015
https://doi.org/10.1371/journal.pone.0145243

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