Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells

Joan Teichenne; Meritxell Morró; Alba Casellas; Veronica Jimenez; Noelia Tellez; Adrien Leger; Fatima Bosch; Eduard Ayuso

doi:10.1371/journal.pone.0145116

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Peer-reviewed

Research Article

Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells

Joan Teichenne,

Affiliations Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Bellaterra, Spain, Department of Biochemistry and Molecular Biology, School of Veterinary Medicine. Universitat Autònoma de Barcelona, Bellaterra, Spain
⨯
Meritxell Morró,

Affiliations Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Bellaterra, Spain, Department of Biochemistry and Molecular Biology, School of Veterinary Medicine. Universitat Autònoma de Barcelona, Bellaterra, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain
⨯
Alba Casellas,

Affiliations Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Bellaterra, Spain, Department of Biochemistry and Molecular Biology, School of Veterinary Medicine. Universitat Autònoma de Barcelona, Bellaterra, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain
⨯
Veronica Jimenez,

Affiliations Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Bellaterra, Spain, Department of Biochemistry and Molecular Biology, School of Veterinary Medicine. Universitat Autònoma de Barcelona, Bellaterra, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain
⨯
Noelia Tellez,

Affiliations CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain, Bellvitge Biomedical Research Institute, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
⨯
Adrien Leger,

Affiliation Laboratoire de Thérapie Génique, INSERM UMR1089, University of Nantes and Atlantic Gene Therapies, Nantes, France
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Fatima Bosch,

Affiliations Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Bellaterra, Spain, Department of Biochemistry and Molecular Biology, School of Veterinary Medicine. Universitat Autònoma de Barcelona, Bellaterra, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain
⨯
Eduard Ayuso

* E-mail: eduard.ayuso@univ-nantes.fr

Affiliations Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Bellaterra, Spain, Department of Biochemistry and Molecular Biology, School of Veterinary Medicine. Universitat Autònoma de Barcelona, Bellaterra, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain, Laboratoire de Thérapie Génique, INSERM UMR1089, University of Nantes and Atlantic Gene Therapies, Nantes, France
⨯

Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells

Joan Teichenne,
Meritxell Morró,
Alba Casellas,
Veronica Jimenez,
Noelia Tellez,
Adrien Leger,
Fatima Bosch,
Eduard Ayuso

Published: December 21, 2015
https://doi.org/10.1371/journal.pone.0145116

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MicroRNAs
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Insulin
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Cell differentiation
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Gene expression
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Diabetes mellitus
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Hyperexpression techniques
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Principal component analysis
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cDNA synthesis
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