Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium

• Abbas Dehghan ,

  Contributed equally to this work with: Abbas Dehghan, Joshua C. Bis, Charles C. White, Albert Vernon Smith, Alanna C. Morrison

  * E-mail: a.dehghan@erasmusmc.nl. (AD); odonnellc@nhlbi.nih.gov (CJO)

  Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

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• Joshua C. Bis ,

  Contributed equally to this work with: Abbas Dehghan, Joshua C. Bis, Charles C. White, Albert Vernon Smith, Alanna C. Morrison

  Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Charles C. White ,

  Contributed equally to this work with: Abbas Dehghan, Joshua C. Bis, Charles C. White, Albert Vernon Smith, Alanna C. Morrison

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America

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• Albert Vernon Smith ,

  Contributed equally to this work with: Abbas Dehghan, Joshua C. Bis, Charles C. White, Albert Vernon Smith, Alanna C. Morrison

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

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• Alanna C. Morrison ,

  Contributed equally to this work with: Abbas Dehghan, Joshua C. Bis, Charles C. White, Albert Vernon Smith, Alanna C. Morrison

  Affiliation Human Genetics Center, and Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, United States of America

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• L. Adrienne Cupples,

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America, Boston University’s and National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, United States of America

  ⨯
• Stella Trompet,

  Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

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• Daniel I. Chasman,

  Affiliation Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Thomas Lumley,

  Affiliations Department of Biostatistics, University of Washington, Seattle, WA, United States of America, Department of Statistics, University of Auckland, Auckland, New Zealand

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• Uwe Völker,

  Affiliations Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany, DZHK (German Center for Cardiovascular Research), partner site, Greifswald, Germany

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• Brendan M. Buckley,

  Affiliation Department of Pharmacology and Therapeutics, University College, Cork, Ireland

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• Jingzhong Ding,

  Affiliation Department of Internal Medicine, Division of Geriatrics, Wake Forest University, Winston-Salem, North Carolina, United States of America

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• Majken K. Jensen,

  Affiliations Department of Nutrition, Harvard School of Public Health, Boston, MA, United States of America, Channing Division of Network Medicine, Harvard Medical School, Boston, MA, United States of America

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• Aaron R. Folsom,

  Affiliation Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, United States of America

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• Stephen B. Kritchevsky,

  Affiliation Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, United States of America

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• Cynthia J. Girman,

  Affiliations Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States of America, Department of Epidemiology, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, NJ, United States of America

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• Ian Ford,

  Affiliation Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Marcus Dörr,

  Affiliations DZHK (German Center for Cardiovascular Research), partner site, Greifswald, Germany, Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Veikko Salomaa,

  Affiliation National Institute for Health and Welfare, Helsinki, Finland

  ⨯
• André G. Uitterlinden,

  Affiliations Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Gudny Eiriksdottir,

  Affiliation Icelandic Heart Association, Kopavogur, Iceland

  ⨯
• Ramachandran S. Vasan,

  Affiliations Boston University’s and National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, United States of America, Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States of America, Department of Medicine, Boston University School of Medicine, Boston, MA, United States of America, Department of Preventive Medicine, Boston University School of Medicine, Boston, MA, United States of America, Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, United States of America

  ⨯
• Nora Franceschini,

  Affiliation Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States of America

  ⨯
• Cara L. Carty,

  Affiliation Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America

  ⨯
• Jarmo Virtamo,

  Affiliation National Institute for Health and Welfare, Helsinki, Finland

  ⨯
• Serkalem Demissie,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America

  ⨯
• Philippe Amouyel,

  Affiliation Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France

  ⨯
• Dominique Arveiler,

  Affiliation Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Strasbourg, France

  ⨯
• Susan R. Heckbert,

  Affiliations Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, WA, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, United States of America

  ⨯
• Jean Ferrières,

  Affiliation Departments of Cardiology and Epidemiology, Toulouse University Hospital, Toulouse, France

  ⨯
• Pierre Ducimetière,

  Affiliation National Institute of Health and Medical Research (U258), Paris, France

  ⨯
• Nicholas L. Smith,

  Affiliations Department of Epidemiology, University of Washington, Seattle, WA, United States of America, Seattle Epidemiologic Research and Information Center of the Department of Veterans Affairs Office of Research and Development, Seattle, WA, United States of America

  ⨯
• Ying A. Wang,

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA, United States of America

  ⨯
• David S. Siscovick,

  Affiliation The New York Academy of Medicine, New York, NY, United States of America

  ⨯
• Kenneth M. Rice,

  Affiliation Department of Biostatistics, University of Washington, Seattle, WA, United States of America

  ⨯
• Per-Gunnar Wiklund,

  Affiliation Department of Medicine, Umeå University Hospital, Umeå, Sweden

  ⨯
• Kent D. Taylor,

  Affiliations Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, CA, United States of America, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States of America

  ⨯
• Alun Evans,

  Affiliation UKCRC Centre of Excellence for Public Health Research (Northern Ireland), Queen’s University of Belfast, Belfast, United Kingdom

  ⨯
• Frank Kee,

  Affiliation UKCRC Centre of Excellence for Public Health Research (Northern Ireland), Queen’s University of Belfast, Belfast, United Kingdom

  ⨯
• Jerome I. Rotter,

  Affiliations Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, CA, United States of America, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States of America

  ⨯
• Juha Karvanen,

  Affiliations National Institute for Health and Welfare, Helsinki, Finland, Department of Mathematics and Statistics, University of Jyväskylä, Jyväskylä, Finland

  ⨯
• Kari Kuulasmaa,

  Affiliation National Institute for Health and Welfare, Helsinki, Finland

  ⨯
• Gerardo Heiss,

  Affiliation Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States of America

  ⨯
• Peter Kraft,

  Affiliation Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States of America

  ⨯
• Lenore J. Launer,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Albert Hofman,

  Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Marcello R. P. Markus,

  Affiliations DZHK (German Center for Cardiovascular Research), partner site, Greifswald, Germany, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Lynda M. Rose,

  Affiliation Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Kaisa Silander,

  Affiliations National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland

  ⨯
• Peter Wagner,

  Affiliations National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland

  ⨯
• Emelia J. Benjamin,

  Affiliations Boston University’s and National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, United States of America, Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States of America, Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, United States of America

  ⨯
• Kurt Lohman,

  Affiliation Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, United States of America

  ⨯
• David J. Stott,

  Affiliation Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Fernando Rivadeneira,

  Affiliations Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands

  ⨯
• Tamara B. Harris,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Daniel Levy,

  Affiliation Boston University’s and National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, United States of America

  ⨯
• Yongmei Liu,

  Affiliation Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, United States of America

  ⨯
• Eric B. Rimm,

  Affiliations Department of Nutrition, Harvard School of Public Health, Boston, MA, United States of America, Channing Division of Network Medicine, Harvard Medical School, Boston, MA, United States of America

  ⨯
• J. Wouter Jukema,

  Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands, Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands

  ⨯
• Henry Völzke,

  Affiliations DZHK (German Center for Cardiovascular Research), partner site, Greifswald, Germany, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Paul M. Ridker,

  Affiliation Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Stefan Blankenberg ,

  ¶‡ These authors also contributed equally to this work.

  Affiliation Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Oscar H. Franco ,

  ¶‡ These authors also contributed equally to this work.

  Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

  ⨯
• Vilmundur Gudnason ,

  ¶‡ These authors also contributed equally to this work.

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

  ⨯
• Bruce M. Psaty ,

  ¶‡ These authors also contributed equally to this work.

  Affiliations Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, WA, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, United States of America, Department of Health Services, University of Washington, Seattle, WA, United States of America

  ⨯
• Eric Boerwinkle ,

  ¶‡ These authors also contributed equally to this work.

  Affiliations Human Genetics Center, and Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, United States of America, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America

  ⨯
•  [ ... ],
• Christopher J. O'Donnell

  * E-mail: a.dehghan@erasmusmc.nl. (AD); odonnellc@nhlbi.nih.gov (CJO)

  ¶‡ These authors also contributed equally to this work.

  Affiliations Boston University’s and National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, United States of America, Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD, United States of America, Cardiology Section, Department of Medicine, Boston Veteran’s Administration Healthcare, Boston, MA, United States of America

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