Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts

Y. Terry Lee; Jaira F. de Vasconcellos; Colleen Byrnes; Megha Kaushal; Antoinette Rabel; Laxminath Tumburu; Joshua M. Allwardt; Jeffery L. Miller

doi:10.1371/journal.pone.0144977

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Peer-reviewed

Research Article

Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts

Y. Terry Lee ,

Contributed equally to this work with: Y. Terry Lee, Jaira F. de Vasconcellos

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Jaira F. de Vasconcellos ,

Contributed equally to this work with: Y. Terry Lee, Jaira F. de Vasconcellos

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Colleen Byrnes,

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Megha Kaushal,

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Antoinette Rabel,

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Laxminath Tumburu,

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Joshua M. Allwardt,

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Jeffery L. Miller

* E-mail: jm7f@nih.gov

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts

Y. Terry Lee,
Jaira F. de Vasconcellos,
Colleen Byrnes,
Megha Kaushal,
Antoinette Rabel,
Laxminath Tumburu,
Joshua M. Allwardt,
Jeffery L. Miller

Published: December 16, 2015
https://doi.org/10.1371/journal.pone.0144977

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MicroRNAs
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Globins
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Polymerase chain reaction
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Adults
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Hemoglobin
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Cell differentiation
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Gene expression
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