The Contrasting Role of p16Ink4A Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations

Nicola Fusco; Elena Guerini-Rocco; Alessandro Del Gobbo; Renato Franco; Federica Zito-Marino; Valentina Vaira; Gaetano Bulfamante; Giulia Ercoli; Mario Nosotti; Alessandro Palleschi; Silvano Bosari; Stefano Ferrero

doi:10.1371/journal.pone.0144923

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Peer-reviewed

Research Article

The Contrasting Role of p16^Ink4A Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations

Nicola Fusco,

Affiliation Division of Pathology, Fondazione IRCCS Ca’ Granda—Ospedale Maggiore Policlinico, Milan, Italy
⨯
Elena Guerini-Rocco,

Current address: Department of Pathology, European Institute of Oncology, Milan, Italy

Affiliation Division of Pathology, Fondazione IRCCS Ca’ Granda—Ospedale Maggiore Policlinico, Milan, Italy
⨯
Alessandro Del Gobbo,

Affiliation Division of Pathology, Fondazione IRCCS Ca’ Granda—Ospedale Maggiore Policlinico, Milan, Italy
⨯
Renato Franco,

Affiliation Department of Pathology, Istituto Nazionale Tumori—IRCCS Fondazione Pascale, Naples, Italy
⨯
Federica Zito-Marino,

Affiliation Department of Pathology, Istituto Nazionale Tumori—IRCCS Fondazione Pascale, Naples, Italy
⨯
Valentina Vaira,

Affiliations Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy, Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy
⨯
Gaetano Bulfamante,

Affiliation Division of Pathology, San Paolo Hospital; Department of Health Sciences, University of Milan, Milan, Italy
⨯
Giulia Ercoli,

Affiliation Division of Pathology, Fondazione IRCCS Ca’ Granda—Ospedale Maggiore Policlinico, Milan, Italy
⨯
Mario Nosotti,

Affiliation Division of Thoracic Surgery, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy
⨯
Alessandro Palleschi,

Affiliation Division of Thoracic Surgery, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy
⨯
Silvano Bosari ,

¶‡ These authors jointly directed this work.

Affiliations Division of Pathology, Fondazione IRCCS Ca’ Granda—Ospedale Maggiore Policlinico, Milan, Italy, Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy
⨯
Stefano Ferrero

* E-mail: stefano.ferrero@unimi.it

¶‡ These authors jointly directed this work.

Affiliations Division of Pathology, Fondazione IRCCS Ca’ Granda—Ospedale Maggiore Policlinico, Milan, Italy, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
⨯

The Contrasting Role of p16^Ink4A Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations

Nicola Fusco,
Elena Guerini-Rocco,
Alessandro Del Gobbo,
Renato Franco,
Federica Zito-Marino,
Valentina Vaira,
Gaetano Bulfamante,
Giulia Ercoli,
Mario Nosotti,
Alessandro Palleschi

Published: December 16, 2015
https://doi.org/10.1371/journal.pone.0144923

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