Selective Loss of Early Differentiated, Highly Functional PD1high CD4 T Cells with HIV Progression

Robert M. Paris; Constantinos Petrovas; Sara Ferrando-Martinez; Eirini Moysi; Kristin L. Boswell; Eva Archer; Takuya Yamamoto; David Ambrozak; Joseph P. Casazza; Richard Haubrich; Mark Connors; Julie Ake; Jerome H. Kim; Richard A. Koup

doi:10.1371/journal.pone.0144767

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Open Access

Peer-reviewed

Research Article

Selective Loss of Early Differentiated, Highly Functional PD1^high CD4 T Cells with HIV Progression

Robert M. Paris,

Affiliations Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America, United States Military HIV Research Program, Silver Spring, Maryland, United States of America
⨯
Constantinos Petrovas ,

* E-mail: petrovasc@mail.nih.gov

Affiliation Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
⨯
Sara Ferrando-Martinez,

Affiliation Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
⨯
Eirini Moysi,

Affiliations Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America, Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, Florida, United States of America
⨯
Kristin L. Boswell,

Affiliation Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
⨯
Eva Archer,

Affiliation Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
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Takuya Yamamoto,

Affiliation Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
⨯
David Ambrozak,

Affiliation Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
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Joseph P. Casazza,

Affiliation Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
⨯
Richard Haubrich,

Affiliation Division of Infectious Diseases, Antiviral Research Center, University of California San Diego, San Diego, California, United States of America
⨯
Mark Connors,

Affiliation HIV-Specific Immunity Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America
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Julie Ake,

Affiliation United States Military HIV Research Program, Silver Spring, Maryland, United States of America
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Jerome H. Kim,

Affiliation International Vaccine Institute, Seoul, South Korea
⨯
Richard A. Koup

Affiliation Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
⨯

Selective Loss of Early Differentiated, Highly Functional PD1^high CD4 T Cells with HIV Progression

Robert M. Paris,
Constantinos Petrovas,
Sara Ferrando-Martinez,
Eirini Moysi,
Kristin L. Boswell,
Eva Archer,
Takuya Yamamoto,
David Ambrozak,
Joseph P. Casazza,
Richard Haubrich

Published: December 17, 2015
https://doi.org/10.1371/journal.pone.0144767

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